ArticlePloS one2020
Total small vessel disease burden and functional outcome in patients with ischemic stroke.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Comparative Diagnostic and Prognostic Performance of SWI and T2-Weighted MRI in Cerebral Microbleed Detection Following Acute Ischemic Stroke: A Meta-Analysis and SPOT-CMB Study.Medicina (Kaunas, Lithuania) · 2025Pooled it
- Differential impact of cumulative cerebral small-vessel disease burden on ischemic versus hemorrhagic stroke recurrence in hemorrhage-prone patients.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Trial
- Magnetic Resonance Imaging-Defined Cerebral Small Vessel Disease Burden and Longitudinal Neuropsychiatric and Functional Recovery After Stroke: A Prospective Cohort Study.Neurology international · 2026Article
- Multimodal Magnetic Resonance Imaging Signatures of White Matter Hyperintensities: Mechanistic Insights Into Pathobiological Heterogeneity.Journal of stroke · 2026Review
- Blood pressure variability and parenchymal hematoma after endovascular thrombectomy: effect modification by recanalization status and cerebral small vessel disease burden.Frontiers in neurology · 2026Article
- Small vessel disease increases risk of poor outcome through stroke and dementia.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Observational
- The Relationship Between Blood Omega-3 Levels and the Small Vessel Disease in Ischemic Stroke Patients: A Case-Control Study.Health science reports · 2025Article
- The Relationship Between Brain Frailty and Physical Function in Patients With Stroke Undergoing Rehabilitation.Cureus · 2025Article
- The combination of atrial fibrillation and small vessel disease score worsen spontaneous intracerebral hemorrhage outcomes.Frontiers in neurology · 2025Article
- Brain Frailty and Outcomes of Acute Minor Ischemic Stroke With Large-Vessel Occlusion.Journal of clinical neurology (Seoul, Korea) · 2024Article
- Article
- The Relevance of Serum Macrophage Migration Inhibitory Factor Level and Executive Function in Patients with White Matter Hyperintensity in Cerebral Small Vessel Disease.Brain sciences · 2023Article
- Small vessel disease burden predicts functional outcomes in patients with acute ischemic stroke using machine learning.CNS neuroscience & therapeutics · 2023Article
- Exploring the Impact of Cerebral Microbleeds on Stroke Management.Neurology international · 2023Review
- Brain Enlarged Perivascular Spaces as Imaging Biomarkers of Cerebrovascular Disease: A Clinical Narrative Review.Journal of the American Heart Association · 2022Review
- The Clinical Utility of Leukoaraiosis as a Prognostic Indicator in Ischemic Stroke Patients.Neurology international · 2022Review
- Machine learning approach for hemorrhagic transformation prediction: Capturing predictors' interaction.Frontiers in neurology · 2022Article
- Influence of Pre-Existing Cerebral Small Vessel Disease on the Outcome of Acute Cardioembolic Stroke: A Retrospective Study.Neuropsychiatric disease and treatment · 2022Article
- Contribution of Inflammation and Hypoperfusion to White Matter Hyperintensities-Related Cognitive Impairment.Frontiers in neurology · 2021Article
- Impact of cerebral small vessel disease burden and systemic clinical phenotypes on short-term neurological outcomes after acute ischemic stroke.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCerebral small vessel disease (SVD) is comprised of lacunes, cerebral microbleeds (CMBs), white matter hyperintensities (WMHs), and enlarged perivascular space (EPVS). We investigated the cumulative effect of SVD on 3-month functional outcome following ischemic stroke using the total SVD score.
methodsThe total SVD score of 477 acute ischemic stroke patients with adequate brain MRI was analyzed. We used multivariable ordinal logistic regression analysis to investigate the independent impact of total SVD score on ordinal modified Rankin Scale (mRS) score at 3-month after ischemic stroke.
resultsMean age was 66±14 years, and 61% were men. The distribution of the total SVD score from 0 to 4 was 27%, 24%, 26%, 16%, and 7%, respectively. The proportion of mRS scores 2 or greater was 16% and 47% in total SVD score 0 and 4, respectively. Multivariable ordinal logistic regression analysis results showed that compared with the total SVD score of 0, total SVD scores of 2, 3, and 4 were independently associated with higher mRS scores with adjusted odds ratios (95% confidence intervals) of 1.68 (1.02-2.76), 2.24 (1.25-4.00), and 2.00 (1.02-4.29). Lacunes, CMBs, WMHs but not EPVS were associated with mRS scores at 3 months. However, the impact of each SVD marker on stroke outcome was smaller than that of the total SVD score.
conclusionWe found an independent association between total SVD scores and functional outcome at 3 months following ischemic stroke. The total SVD score may be useful for stratification of patients who are at a high-risk of unfavorable outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.