Evidence map›Paper›PMID 33180791›Full record

ArticlePloS one2020

Bone mineral density in Palestinian patients with end-stage renal disease and the related clinical and biochemical factors: Cross-sectional study.

Zaher Nazzal, Shahd Khader, Hiba Zawyani, Mazen Abdallah, Osama Sawalmeh, Zakaria Hamdan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Zaher NazzalFamily and Community Medicine Department, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine.ORCID 0000-0002-2655-6109
Shahd KhaderMedicine Department, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine.
Hiba ZawyaniMedicine Department, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine.
Mazen AbdallahOrthopedic Surgery Department, An-Najah National University Hospital, An-Najah National University, Nablus, Palestine.ORCID 0000-0002-9837-1875
Osama SawalmehInternal Medicine Department, An-Najah National University Hospital, An-Najah National University, Nablus, Palestine.ORCID 0000-0002-5733-2589
Zakaria HamdanNephrology Consultant, Nephrology Department, An-Najah National University Hospital, An-Najah National University, Nablus, Palestine.
An-Najah National University · PS

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionEnd-Stage Renal Disease (ESRD) is the ultimate result of chronic kidney disease (CKD). In Palestine, the prevalence of ESRD was 240.3 PMP which is comparable with the nearby countries. Accelerated bone loss among ESRD patients is attributed to abnormal bone turn over that leads to osteoporosis and osteopenia. The risk of fractures is increased four-fold in men and women on hemodialysis, which explains the importance of assessing the bone mineral density among these population. The goals of this study were to find the prevalence of osteoporosis in ESRD patients as determined by bone mineral density (BMD) at different sites and to determine whether BMD correlates with many other clinical parameters.

methodsA cross-sectional study of 194 ESRD patients were recruited from the dialysis unit in An-Najah National University Hospital, Nablus, Palestine. The patients were on regular hemodialysis or peritoneal dialysis. BMD was measured at the lumbar spine and the hip using the dual-energy X-Ray absorptiometry (DEXA) and the value is expressed as T-score. The data were analyzed using SPSS, version 26. The relationship between BMD and the clinical and biochemical parameters among the ESRD patients was assessed.

resultsWe found that 42.8% of ESRD patient had osteoporosis and 40.2% had osteopenia. There were significantly higher proportions of osteoporosis and osteopenia among patients >60 years of age (p<0.005). Patients with osteoporosis and osteopenia had significantly higher serum levels of PTH (792.9 and 469.7) (p<0.05). BMD decreases as the duration of dialysis (39.0 months Vs. 56.8 months), (p<0.05). We found no significant difference between patients on hemodialysis or peritoneal dialysis.

conclusionThis study showed that Palestinian patients with ESRD have low BMD at the hip and spine. The observed high serum level of PTH was associated with low BMD. Those patients should be closely monitored especially those with more than one risk factor. Moreover, more attention should be paid for these category of patients to decrease the incidence of falling down and the resulting fractures that might lead to mortality and morbidity.

Indexed as

Absorptiometry, PhotonArabsBone DensityBone Diseases, MetabolicCross-Sectional StudiesFemaleFemur NeckHumansKidney Failure, ChronicLumbar VertebraeMaleMiddle AgedOsteoporosisPeritoneal DialysisRenal DialysisRenal Insufficiency, Chronic

Identifiers

PMID33180791
PMCPMC7661051
OpenAlexW3105757429

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.