Evidence map›Paper›PMID 33180773›Full record

ArticlePLoS biology2020

Superspreading events in the transmission dynamics of SARS-CoV-2: Opportunities for interventions and control.

Benjamin M Althouse, Edward A Wenger, Joel C Miller, Samuel V Scarpino, Antoine Allard, Laurent Hébert-Dufresne, Hao Hu

Abstract read
In one paragraph

Article in PLoS biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 169 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
169citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

169 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. The role of asymptomatic and pre-symptomatic infection in SARS-CoV-2 transmission-a living systematic review.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2021
    Pooled it
  6. Trial
  7. Article
  8. Article
  9. Mechanics of pandemics.EClinicalMedicine · 2026
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Complex multiannual cycles ofProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  16. Article
  17. Article
  18. Uncovering heterogeneous intercommunity disease transmission from neutral allele frequency time series.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  19. Review
  20. The Kinship Formula: Inferring the numbers of all kin from any structured population projection model.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article

109 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Benjamin M AlthouseInstitute for Disease Modeling, Bellevue, Washington, United States of America.
Edward A WengerInstitute for Disease Modeling, Bellevue, Washington, United States of America.
Joel C MillerSchool of Engineering and Mathematical Sciences, La Trobe University, Bundoora, Victoria, Australia.ORCID 0000-0003-4426-0405
Samuel V ScarpinoNetwork Science Institute, Northeastern University, Boston, Massachusetts, United States of America.ORCID 0000-0001-5716-2770
Antoine AllardDépartement de Physique, de Génie Physique et d'Optique, Université Laval, Québec, Québec, Canada.ORCID 0000-0002-8208-9920
Laurent Hébert-DufresneDépartement de Physique, de Génie Physique et d'Optique, Université Laval, Québec, Québec, Canada.
Hao HuBill & Melinda Gates Foundation, Seattle, Washington, United States of America.

Funding

Using Dengue Controlled Human Infection Model to Identify Adaptive Immune Correlates of ProtectionP20GM125498 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI Ellen Kozelka · 2018 to 2026
$24.9M
NIGMS NIH HHS P20 GM125498NIH HHS 1P20 GM125498-01
6 · The paper itself

Abstract

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the etiological agent of the Coronavirus Disease 2019 (COVID-19) disease, has moved rapidly around the globe, infecting millions and killing hundreds of thousands. The basic reproduction number, which has been widely used-appropriately and less appropriately-to characterize the transmissibility of the virus, hides the fact that transmission is stochastic, often dominated by a small number of individuals, and heavily influenced by superspreading events (SSEs). The distinct transmission features of SARS-CoV-2, e.g., high stochasticity under low prevalence (as compared to other pathogens, such as influenza), and the central role played by SSEs on transmission dynamics cannot be overlooked. Many explosive SSEs have occurred in indoor settings, stoking the pandemic and shaping its spread, such as long-term care facilities, prisons, meat-packing plants, produce processing facilities, fish factories, cruise ships, family gatherings, parties, and nightclubs. These SSEs demonstrate the urgent need to understand routes of transmission, while posing an opportunity to effectively contain outbreaks with targeted interventions to eliminate SSEs. Here, we describe the different types of SSEs, how they influence transmission, empirical evidence for their role in the COVID-19 pandemic, and give recommendations for control of SARS-CoV-2.

Indexed as

CoinfectionCOVID-19Disease OutbreaksHumansPoisson DistributionSARS-CoV-2Stochastic Processes

Identifiers

PMID33180773
PMCPMC7685463

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.