ArticleAmerican journal of respiratory and critical care medicine2021
Mucus Plugs and Emphysema in the Pathophysiology of Airflow Obstruction and Hypoxemia in Smokers.
Abstract readComparative Study
In one paragraph
Article in American journal of respiratory and critical care medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 112 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
112citing papers in PubMed, 2 pooled it
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
112 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effectiveness of biologics for reducing occlusive mucus plugs in patients with severe asthma: a systematic review.Respiratory research · 2026Pooled it
- Association Between Non-obstructive Chronic Bronchitis and Incident Chronic Obstructive Pulmonary Disease and All-Cause Mortality: A Systematic Review and Meta-Analysis.Frontiers in medicine · 2021Pooled it
- Effect of lateral versus supine positioning on hypoxaemia in sedated adults: multicentre randomised controlled trial.BMJ (Clinical research ed.) · 2025Trial
- Icenticaftor, a CFTR Potentiator, in COPD: A Multicenter, Parallel-Group, Double-Blind Clinical Trial.American journal of respiratory and critical care medicine · 2023Trial
- Radiologist and AI performance in detecting mucus plugs on chest CT.European radiology · 2026Article
- Airway mucus plugs in asthma and chronic obstructive pulmonary disease: pathobiology, imaging, and implications for clinical trials.American journal of respiratory and critical care medicine · 2026Review
- Eosinophil biology in COPD: from scientific insight to clinical treatment action.ERJ open research · 2026Review
- Chest CT imaging toward personalized management of chronic obstructive pulmonary disease, asthma, and bronchiectasis: pulmonologist perspectives.Japanese journal of radiology · 2026Review
- Association of Airway Mucus Plugs and Physical Activity, Exercise Tolerance, Sarcopenia, and Frailty in Patients With COPD and Pre-COPD.Respirology (Carlton, Vic.) · 2026Observational
- From ideal respiratory health to chronic lung disease: indicators of impaired respiratory health.Expert review of respiratory medicine · 2026Review
- Precision treatment of COPD based on novel imaging phenotypes: a treatable traits approach.Respiratory research · 2026Review
- Characterization of mucus plugging in patients with chronic obstructive pulmonary disease: additional clinical significance of asthma-like features.BMC pulmonary medicine · 2026Article
- Airway secretory cells contain both a perinuclear Golgi ribbon and dispersed Golgi satellites.American journal of respiratory cell and molecular biology · 2026Article
- Periostin and airway mucus plugs in nonasthmatic former smokers with and without COPD.ERJ open research · 2026Article
- Real-World Dupilumab in Type 2 Chronic Obstructive Pulmonary Disease (COPD): A Single-Centre Compassionate-Use Case Series.Biomedicines · 2026Article
- Artificial Intelligence-Based Detection of Airway Mucus Plugs on CT and Associations With Clinical Outcomes in COPDGene.medRxiv : the preprint server for health sciences · 2026Article
- Clinical and Radiological Characteristics of Symptomatic Emphysema Patients with PRISm and Pre-COPD Phenotypes: Possible Effects of Smoking Status.Biomedicines · 2026Article
- Effect of airway constriction on ventilation inhomogeneity: multiple-breath washout indices and intrapulmonary reverse flow.Respiratory research · 2026Article
- Quantitative CT of emphysema, wall thickness and mucus plugs in alpha-1-antitrypsin deficiency: relationship to clinical outcomes.European radiology · 2026Article
- Severe Hypoxia Reduces Adenylyl Cyclase 6 Expression and Function in Bronchial Epithelial Cells.FASEB bioAdvances · 2026Article
52 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
34 authors.
Eleanor M DunicanEducation and Research Centre, St. Vincent's University Hospital, School of Medicine, University College Dublin, Dublin, Ireland.ORCID 0000-0003-4014-5100
Brett M ElickerDepartment of Radiology and Biomedical Imaging.
Travis HenryDepartment of Radiology and Biomedical Imaging.
David S GieradaMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri.
Mark L SchieblerDepartment of Medical Physics and.
Wayne AndersonDivision of Pulmonary and Critical Care Medicine, Department of Medicine.
Igor BarjaktarevicDivision of Pulmonary and Critical Care Medicine, Department of Medicine, University of California Los Angeles, Los Angeles, California.
R Graham BarrDivision of General Medicine, Department of Medicine, Columbia University, New York City, New York.
Eugene R BleeckerDivision of Genetics, Genomics, and Precision Medicine, Department of Medicine, University of Arizona, Tucson, Arizona.
Richard C BoucherMarsico Lung Institute/UNC Cystic Fibrosis Center, and.
Russell BowlerDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, National Jewish Health, Denver, Colorado.
Stephanie A ChristensonDivision of Pulmonary and Critical Care Medicine, Department of Medicine.
Alejandro ComellasDivision of Pulmonary, Critical Care, and Occupational Medicine, Department of Internal Medicine.ORCID 0000-0003-1521-7520
Christopher B CooperDivision of Pulmonary and Critical Care Medicine, Department of Medicine, University of California Los Angeles, Los Angeles, California.
David CouperCollaborative Studies Coordinating Center, Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Gerard J CrinerDepartment of Thoracic Medicine and Surgery, Temple University, Philadelphia, Pennsylvania.
Mark DransfieldDivision of Pulmonary, Allergy, & Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Claire M DoerschukMarsico Lung Institute/UNC Cystic Fibrosis Center, and.
M Bradley DrummondDivision of Pulmonary and Critical Care Medicine, Department of Medicine.ORCID 0000-0002-6968-4610
Nadia N HanselDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland.
MeiLan K HanDivision of Pulmonary and Critical Care Medicine, Department of Medicine, University of Michigan at Ann Arbor, Ann Arbor, Michigan.
Annette T HastiePulmonary, Critical Care, Allergy, and Immunologic Medicine, Department of Internal Medicine, Wake Forest University, Winston-Salem, North Carolina.ORCID 0000-0001-6607-7797
Eric A HoffmanDepartment of Radiology.
Jerry A KrishnanDivision of Pulmonary, Critical Care, Sleep, and Allergy, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois.ORCID 0000-0001-5525-4778
Stephen C LazarusDivision of Pulmonary and Critical Care Medicine, Department of Medicine.
Fernando J MartinezDivision of Pulmonary and Critical Care Medicine, Weill Cornell Medicine and New York-Presbyterian Weill Cornell Medical Center, New York, New York.
Charles E McCullochDepartment of Epidemiology and Biostatistics, School of Medicine, University of California San Francisco, San Francisco, California.
Wanda K O'NealMarsico Lung Institute/UNC Cystic Fibrosis Center, and.
Victor E OrtegaPulmonary, Critical Care, Allergy, and Immunologic Medicine, Department of Internal Medicine, Wake Forest University, Winston-Salem, North Carolina.
Robert PaineDivision of Pulmonary and Critical Care Medicine, Department of Medicine, University of Utah Hospitals and Clinics, Salt Lake City, Utah.
Stephen PetersPulmonary, Critical Care, Allergy, and Immunologic Medicine, Department of Internal Medicine, Wake Forest University, Winston-Salem, North Carolina.
Joyce D SchroederDepartment of Radiology, University of Utah School of Medicine, Salt Lake City, Utah.
Prescott G WoodruffDivision of Pulmonary and Critical Care Medicine, Department of Medicine.
John V FahyDivision of Pulmonary and Critical Care Medicine, Department of Medicine.
Funding
Understanding Asthma EndotypesU19AI077439 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PRESCOTT G WOODRUFF · 2008 to 2026
$41.1MPulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5MSPIROMICS II: Biological underpinnings of COPD heterogeneity and progressionU01HL137880 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WOODRUFF, PRESCOTT G · 2017 to 2021
$27.9MRole of miRNAs in Th2-Driven inflammation in AsthmaP01HL107202 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FAHY, JOHN V · 2012 to 2023
$23.3MPre Clinical and Clinical Development of a Novel Thiol-Saccharide MucolyticP01HL128191 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LAZARUS, STEPHEN C · 2016 to 2020
$13.4MProtein carbohydrate interactions in the pathophysiology of asthma exacerbationsR01HL080414 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI John V Fahy · 2005 to 2026
$9.2MSPIROMICS GIC SupportU24HL141762 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COUPER, DAVID J, O'NEAL, WANDA K · 2018 to 2022
$7.2MIdentifying the Th2 endotype in COPD: clinical and pathologic implicationsK23HL123778 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHRISTENSON, STEPHANIE A · 2015 to 2019
$847kNHLBI NIH HHS HHSN268200900013CNHLBI NIH HHS HHSN268200900014CNHLBI NIH HHS HHSN268200900015CNHLBI NIH HHS HHSN268200900016CNHLBI NIH HHS HHSN268200900017CNHLBI NIH HHS HHSN268200900018CNHLBI NIH HHS HHSN268200900019CNHLBI NIH HHS HHSN268200900020CNHLBI NIH HHS K23 HL123778NHLBI NIH HHS P01 HL107202NHLBI NIH HHS P01 HL128191NHLBI NIH HHS R01 HL080414NHLBI NIH HHS U01 HL137880NHLBI NIH HHS U24 HL141762NIAID NIH HHS U19 AI077439NIEHS NIH HHS P30 ES005605
Abstract
PubMed holds no abstract for this paper.
Indexed as
MucusAgedFemaleForced Expiratory VolumeHealthy VolunteersHumansHypoxiaMaleMiddle AgedPulmonary Disease, Chronic ObstructivePulmonary EmphysemaRespiratory Function TestsSmokersSmokingVital Capacitycomputed tomographyCOPDemphysemaFEV1mucus plugs
Identifiers
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Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.