ArticleNeuroscience bulletin2021
Projections from Infralimbic Cortex to Paraventricular Thalamus Mediate Fear Extinction Retrieval.
Article in Neuroscience bulletin, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 43 citations in OpenAlex.
- Social support facilitates threat extinction retention in humans: an fMRI study.Translational psychiatry · 2025Trial
- DNMT1-mediated central amygdala to locus coeruleus circuit contributes to chronic pain-related depression in mice.Acta pharmacologica Sinica · 2026Article
- Excitatory paraventricular thalamus-posterior insular cortex circuit mediates pain-anxiety comorbidity in diabetic neuropathy.Translational psychiatry · 2026Article
- Respiratory-Limbic Coupling via a Thalamic Circuit Alleviates Anxiety.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The anterior paraventricular thalamus counteracts fear expression during retrieval through both amygdala and subiculum circuits.Communications biology · 2025Article
- Mild Traumatic Brain Injury Impairs Fear Extinction and Network Excitability in the Infralimbic Cortex.Journal of neurotrauma · 2025Article
- nNOS-expressing neurons in the mPFC mediate depression-related behaviors in mice through pPVT-mPFC projections.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Neural and molecular investigation into the paraventricular thalamus for chronic restraint stress induced depressive-like behaviors.Journal of advanced research · 2025Article
- How Fear Memory is Updated: From Reconsolidation to Extinction?Neuroscience bulletin · 2025Review
- Infralimbic Projections to the Substantia Innominata-Ventral Pallidum Constrain Defensive Behavior during Extinction Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Sex Differences in Neural Circuits Underlying Fear Processing.Current topics in behavioral neurosciences · 2025Review
- Article
- Dynamic Changes of the Infralimbic Cortex and Its Regulation of the Prelimbic Cortex in Rats with Chronic Inflammatory Pain.Neuroscience bulletin · 2024Article
- Memory Trace for Fear Extinction: Fragile yet Reinforceable.Neuroscience bulletin · 2024Review
- Paraventricular thalamus-insular cortex circuit mediates colorectal visceral pain induced by neonatal colonic inflammation in mice.CNS neuroscience & therapeutics · 2024Article
- Article
- Expanding the canon: An inclusive neurobiology of thalamic and subthalamic fear circuits.Neuropharmacology · 2023Review
- Learning processes in relapse to alcohol use: lessons from animal models.Psychopharmacology · 2023Review
- The impact of environmental factors during maternal separation on the behaviors of adolescent C57BL/6 mice.Frontiers in molecular neuroscience · 2023Article
- MicroRNA expression profiles of stress susceptibility and resilience in the prelimbic and infralimbic cortex of rats after single prolonged stress.Frontiers in psychiatry · 2023Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The paraventricular nucleus of the thalamus (PVT), which serves as a hub, receives dense projections from the medial prefrontal cortex (mPFC) and projects to the lateral division of central amygdala (CeL). The infralimbic (IL) cortex plays a crucial role in encoding and recalling fear extinction memory. Here, we found that neurons in the PVT and IL were strongly activated during fear extinction retrieval. Silencing PVT neurons inhibited extinction retrieval at recent time point (24 h after extinction), while activating them promoted extinction retrieval at remote time point (7 d after extinction), suggesting a critical role of the PVT in extinction retrieval. In the mPFC-PVT circuit, projections from IL rather than prelimbic cortex to the PVT were dominant, and disrupting the IL-PVT projection suppressed extinction retrieval. Moreover, the axons of PVT neurons preferentially projected to the CeL. Silencing the PVT-CeL circuit also suppressed extinction retrieval. Together, our findings reveal a new neural circuit for fear extinction retrieval outside the classical IL-amygdala circuit.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.