Evidence map›Paper›PMID 33180273›Full record

ArticleForensic science, medicine, and pathology2021

A fatal case after an intravenous injection of levamisole.

Bénédicte Lelièvre, Benoit Suply, François Schmitt, Pascale Marcorelles, Guillaume Drevin, Clotilde Rougé Maillart

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Forensic science, medicine, and pathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 1 country.

Bénédicte LelièvrePharmacology-Toxicology Laboratory, CHU Angers, 49933, Angers, France. belelievre@chu-angers.fr.ORCID http://orcid.org/0000-0003-4014-4028
Benoit SuplyForensic Unit of CHU Brest, Antenne GHBS Lorient, Lorient, France.
François SchmittBiochemistry Laboratory, GHBS Lorient, Lorient, France.
Pascale MarcorellesPathology department, CHU Brest, Brest, France.
Guillaume DrevinPharmacology-Toxicology Laboratory, CHU Angers, 49933, Angers, France.
Clotilde Rougé MaillartAngers University, UFR santé, medicine department, Angers, France.
Centre Hospitalier Universitaire d'Angers · FRCentre Hospitalier de Bretagne Sud · FRCentre Hospitalier Régional Universitaire de Brest · FRLaboratoire de Biologie Structurale de la Cellule · FRUniversité d'Angers · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Levamisole is a drug originally prescribed as an antihelmintic. Because of the occurrence of severe cases of agranulocytosis and leukoencephalitis it was removed from the French market in 1998 for human use, while it remains available for veterinary use. Nowadays in France its only use in humans is regulated by authorization for temporary use for its immunomodulatory properties in the treatment of nephritic syndrome.A 52-year-old man was found dead at his farm. Injection points were observed on his arm and a syringe containing a dark orange-brown liquid was found near the body. At his home, the discovery of a letter highlighted suicidal intent. Analysis of the aforementioned liquid, peripheral blood and urine confirmed the unique presence of levamisole. The femoral blood concentration of levamisole was of 25 mg/L whereas the femoral blood concentrations reported in cases of fatalities after cocaine use do not exceed 0.0056 mg/L. In humans, levamisole can be detected in biological samples after cocaine use as this drug is also an adulterant and one of its metabolites (aminorex) seems to have amphetamine-like properties. In this case, the man consumed levamisole from time to time for its stimulant and strengthening effects.Cases of fatal poisoning using levamisole are very rare and poorly documented, which makes the interpretation of postmortem blood levamisole concentration difficult.

Indexed as

Suicide, CompletedAntinematodal AgentsHumansInjections, IntravenousLevamisoleMaleMiddle AgedAntinematodal AgentsLevamisoleFatalitiesLevamisolePoisoning

Identifiers

PMID33180273
OpenAlexW3104091501

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.