ArticleActa parasitologica2021
First Survey on the Presence and Distribution of Oxytetracycline-Resistance Genes in Anaplasma Species.
Article in Acta parasitologica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 13 citations in OpenAlex.
- Tick-borne pathogens in meat sheep from Brazil: first report of Theileria ovis in sheep in latin America.Parasitology research · 2026Article
- Risk Factors Associated with Hemoparasites in Dual-Purpose Cattle of Colombia.Pathogens (Basel, Switzerland) · 2025Article
- Anaplasmosis in the Amazon: diagnostic challenges, persistence, and control ofFrontiers in veterinary science · 2025Review
- Improvements in Blood Profiles of Canines Naturally Infected with Triple Blood Pathogens (Animals : an open access journal from MDPI · 2024Article
- Molecular identification, risk factor assessment, and phylogenetic analysis of tick-borne pathogens in symptomatic and asymptomatic cattle from South-Eastern Iran.Experimental & applied acarology · 2024Article
- Antibacterial properties and in silico modeling perspective of nano ZnO transported oxytetracycline-ZnThe Journal of antibiotics · 2022Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
introductionAnaplasma sp. is an obligatory intracellular Gram-negative tick-transmitted bacterial pathogen of humans and animals. Oxytetracycline and chlortetracycline are the drugs of choice for treating domestic animals with acute anaplasmosis. Lack of documented information about oxytetracycline resistance in Anaplasma species in the world was the scope of this study to screen by PCR for the detection of the oxytetracycline-resistance genes in Anaplasma species from infected cattle and sheep in the Northwest and Southwest of Iran. MATERIALS AND
methodsTotal of 100 cattle and sheep blood samples collected from 2 provinces in the Northwest and 1 province in the Southwest of Iran were tested microscopically by the Giemsa staining examination and confirmed by PCR. Then the presence of two different oxytetracycline-resistance genes (otrA, and otrB) was detected by PCR in positive samples.
resultsThe results showed that 60% of Anaplasma-infected samples were identified to have an otrA-resistance gene, and 26.67% had an otrB-resistance gene. The coexistence of two oxytetracycline-resistance determinants was encountered in 13.33% of the isolates. The significant difference in the frequency of otr genes was found among three Anaplasma species (A. marginale, A. centrale and A. ovis), and among three studied regions in Iran (p < 0.05). The identified sequences were submitted to the GenBank and deposited under accession numbers MN880729 and MN895439 for otrB and otrA genes.
conclusionThis study, for the first time, indicated the oxytetracycline-resistance genes in the three most prevalent Anaplasma species in ruminants. This finding helps to select an appropriate treatment strategy for eradication of anaplasmosis.
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