Evidence map›Paper›PMID 33180239›Full record

ArticleJournal of gastrointestinal cancer2022

Association of Epidermal Growth Factor 61A>G, Survivin -31G>C, and EFNA1 -1732G>A Polymorphisms with Susceptibility to Colorectal Cancer.

Fatemeh Asadian, Mohammadamin Ghadyani, Mohamad Hossein Antikchi, Seyed Alireza Dastgheib, Hossein Neamatzadeh, Elnaz Sheikhpour, Sahel Khajehnoori, Seyed Sajjad Tabei

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In one paragraph

Article in Journal of gastrointestinal cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Genetic Variants inGenes · 2025
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Fatemeh AsadianDepartment of Medical Laboratory Sciences, School of Paramedical Science, Shiraz University of Medical Sciences, Shiraz, Iran.
Mohammadamin GhadyaniDepartment of Advanced Medical Sciences and Technologies, Islamic Azad University, Science and Research Branch, Tehran, Iran.
Mohamad Hossein AntikchiDepartment of Internal Medicine, Yazd Branch, Islamic Azad University, Yazd, Iran. mhantikchi@yahoo.com.
Seyed Alireza DastgheibDepartment of Medical Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Hossein NeamatzadehMother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Elnaz SheikhpourHematology and Oncology Research Center, Shahid Sadoughi University of Medical Science, Yazd, Iran.
Sahel KhajehnooriMother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Seyed Sajjad TabeiStudent Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Shahid Sadoughi University of Medical Sciences and Health Services · IRShiraz University of Medical Sciences · IRIslamic Azad University, Science and Research Branch · IRIslamic Azad University, Yazd · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGenetic polymorphisms play an important role in the development of colorectal cancer (CRC). Functional variants in the epidermal growth factor (EGF), survivin, and Ephrin A1 (EFNA1) genes have been previously reported to play a potential role in susceptibility to CRC, but these polymorphisms have not been well replicated. The aim of this study was to assess the association of the EGF 61A>G, Survivin -31G>C, and EFNA1 -1732G>A polymorphisms with the susceptibility to CRC in an Iranian population.

methodsA total of 148 cases diagnosed with CRC and 160 healthy subjects were recruited. The EGF 61A>G, survivin -31G>C, and EFNA1 -1732G>A polymorphisms were genotyped using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay.

resultsOur data revealed that the homozygous mutant genotype (CC: OR = 2.895, 95% CI = 1.092-7.673, p = 0.033) and mutant allele (C: OR = 1.629, 95% CI = 1.152-2.303, p = 0.006) of the survivin -31G>C were associated with an increased risk of CRC in the Iranian population. However, our results failed to show an association between the EGF 61A>G and EFNA1 -1732G>A polymorphisms and CRC risk.

conclusionOur results revealed that the survivin -31G>C polymorphism might play an important role in development of CRC in Iranian population. However, no association of EGF 61A>G and EFNA1 -1732G>A polymorphisms with CRC risk was found.

Indexed as

Colorectal NeoplasmsEphrin-A1Epidermal Growth FactorSurvivinCase-Control StudiesGenetic Predisposition to DiseaseGenotypeHumansIranPolymorphism, Single NucleotideBIRC5 protein, humanEFNA1 protein, humanEphrin-A1Epidermal Growth FactorSurvivinAssociationColorectal cancerEphrin A1Epidermal growth factorPolymorphismSurvivin

Identifiers

PMID33180239
OpenAlexW3102115545

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.