Evidence map›Paper›PMID 33180167›Full record

ReviewIntensive care medicine2020

Transfusion in the mechanically ventilated patient.

Nicole P Juffermans, Cécile Aubron, Jacques Duranteau, Alexander P J Vlaar, Daryl J Kor, Jennifer A Muszynski, Philip C Spinella, Jean-Louis Vincent

Open access · hybridAbstract readReview
In one paragraph

Review in Intensive care medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 8 institutions in 4 countries.

Nicole P JuffermansLaboratory of Experimental Intensive Care and Anaesthesiology, Amsterdam University Medical Centre, Location Academic Medical Centre, Amsterdam, The Netherlands.
Cécile AubronMedical Intensive Care, Brest University Hospital, Université de Bretagne Occidentale, Brest, France.
Jacques DuranteauDepartment of Anesthesiology and Critical Care, Bicêtre, Hôpitaux Universitaires Paris Saclay, Université Paris Saclay, AP-HP, Le Kremlin Bicêtre, France.
Alexander P J VlaarLaboratory of Experimental Intensive Care and Anaesthesiology, Amsterdam University Medical Centre, Location Academic Medical Centre, Amsterdam, The Netherlands.
Daryl J KorDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.
Jennifer A MuszynskiDepartment of Pediatrics, Division of Critical Care Medicine, Nationwide Children's Hospital and the Ohio State University College of Medicine, Columbus, OH, USA.
Philip C SpinellaDepartment of Pediatrics, Division of Critical Care Medicine, Washington University in St. Louis, St. Louis, MO, USA.
Jean-Louis VincentDepartment of Intensive Care, Erasme University Hospital, Université Libre de Bruxelles, Route de Lennik 808, 1070, Brussels, Belgium. jlvincent@intensive.org.ORCID 0000-0001-6011-6951
Amsterdam University Medical Centers · NLMayo Clinic in Arizona · USNationwide Children's Hospital · USOLVG · NLUniversité de Bretagne Occidentale · FRUniversité Libre de Bruxelles · BEUniversité Paris-Saclay · FRWashington University in St. Louis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Red blood cell transfusions are a frequent intervention in critically ill patients, including in those who are receiving mechanical ventilation. Both these interventions can impact negatively on lung function with risks of transfusion-related acute lung injury (TRALI) and other forms of acute respiratory distress syndrome (ARDS). The interactions between transfusion, mechanical ventilation, TRALI and ARDS are complex and other patient-related (e.g., presence of sepsis or shock, disease severity, and hypervolemia) or blood product-related (e.g., presence of antibodies or biologically active mediators) factors also play a role. We propose several strategies targeted at these factors that may help limit the risks of associated lung injury in critically ill patients being considered for transfusion.

Indexed as

Respiratory Distress SyndromeTransfusion ReactionBlood TransfusionErythrocyte TransfusionHumansRespiration, ArtificialAcute respiratory distress syndromeAnemiaHypervolemiaInflammatory responseOxygen deliveryTransfusion-associated circulatory overloadTransfusion-related acute lung injury

Identifiers

PMID33180167
PMCPMC7658306
OpenAlexW3104887845

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.