Evidence map›Paper›PMID 33179757›Full record

ArticleBrain imaging and behavior2021

Metabolic syndrome components moderate the association between executive function and functional connectivity in the default mode network.

Janelle T Foret, Maria Dekhtyar, Alex C Birdsill, Hirofumi Tanaka, Andreana P Haley

Abstract read
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In one paragraph

Article in Brain imaging and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Janelle T ForetDepartment of Psychology, The University of Texas at Austin, 108 E Dean Keeton, Stop A8000, Austin, TX, 78712, USA.
Maria DekhtyarDepartment of Psychology, The University of Texas at Austin, 108 E Dean Keeton, Stop A8000, Austin, TX, 78712, USA.
Alex C BirdsillWisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Hirofumi TanakaDepartment of Kinesiology and Health Education, The University of Texas at Austin, Austin, TX, USA.
Andreana P HaleyDepartment of Psychology, The University of Texas at Austin, 108 E Dean Keeton, Stop A8000, Austin, TX, 78712, USA. haley@austin.utexas.edu.

Funding

Neuroimaging Cognitive Vulnerability in HypertensionR01NS075565 · NINDS · UNIVERSITY OF TEXAS AT AUSTIN · PI HALEY, ANDREANA PETROVA · 2011 to 2013
$986k
National Institute of Health R01NS75565, R21AG050898NINDS NIH HHS R01NS075565
6 · The paper itself

Abstract

Middle aged individuals with Metabolic Syndrome are at high risk for cognitive decline. Dyssynchrony in the resting state Default Mode Network is one early indicator of brain vulnerability. We set out to explore the relationship between default mode resting state functional connectivity and cognitive performance in both memory and executive domains at midlife in the presence of Metabolic Syndrome components. Seed-based Correlation Analyses were performed between the seed voxel in the posterior cingulate cortex and the medial prefrontal cortex on 200 participants (ages 40-61). Executive domain scores were significantly predicted by the interaction between number of Metabolic Syndrome components and resting state connectivity in the Default Mode Network (p = .004) such that connectivity was negatively related to executive function at higher numbers of Metabolic Syndrome components. Results were not significant for memory. Our findings indicate that clusters of cardiovascular disease risk factors alter functional relationships in the brain and highlights the need to continue exploring how compensatory techniques might operate to support cognitive performance at midlife.

Indexed as

Executive FunctionMetabolic SyndromeAdultBrainBrain MappingDefault Mode NetworkHumansMagnetic Resonance ImagingMiddle AgedNerve NetNeuropsychological TestsAgingCognitive impairmentFunctional connectivityMetabolic syndromeNeuropsychological assessment

Identifiers

PMID33179757

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.