ArticleAmerican journal of hypertension2021
Variability of Aldosterone Measurements During Adrenal Venous Sampling for Primary Aldosteronism.
Article in American journal of hypertension, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Performance of Confirmatory Tests for Diagnosing Primary Aldosteronism: a Systematic Review and Meta-Analysis.Hypertension (Dallas, Tex. : 1979) · 2022Pooled it
- Comparative Analysis of Single-Path and Multipath Adrenal Venous Sampling in Primary Aldosteronism.Journal of interventional cardiology · 2023Trial
- Optimizing adrenal vein sampling interpretation for primary aldosteronism subtyping.Endocrine · 2026Article
- Is It Time to Retire Aldosterone Suppression Testing?American journal of hypertension · 2026Review
- Article
- Nationwide, Pragmatic, Direct-to-Patient Primary Aldosteronism Testing Program.Hypertension (Dallas, Tex. : 1979) · 2025Article
- Intraprotocol Adrenal Vein Sampling Inconsistencies in Primary Aldosteronism Lateralization.Radiology · 2025Article
- Accuracy of semi-quantitative gold nanoparticle-based quick cortisol assay with and without adrenocorticotropic hormone infusion during adrenal vein sampling.Journal of human hypertension · 2025Article
- Usefulness of the Upright Posture Test in the Diagnosis of Primary Aldosteronism.Journal of the Endocrine Society · 2024Article
- The Spectrum of Dysregulated Aldosterone Production: An International Human Physiology Study.The Journal of clinical endocrinology and metabolism · 2024Article
- Shifting paradigms in primary aldosteronism: reconsideration of screening strategy via integrating pathophysiological insights.Frontiers in endocrinology · 2024Review
- Impact of Conducting Adrenal Venous Sampling in the Morning Versus Afternoon in Primary Aldosteronism.Journal of the Endocrine Society · 2023Article
- Primary Aldosteronism: State-of-the-Art Review.American journal of hypertension · 2022Article
- The Entity of Connshing Syndrome: Primary Aldosteronism with Autonomous Cortisol Secretion.Diagnostics (Basel, Switzerland) · 2022Review
- Successful Adrenal Vein Sampling Using Dexamethasone Premedication in Patients With Iodine Contrast Media Allergy.Journal of the Endocrine Society · 2022Article
- Morphologically Normal-Appearing Adrenal Glands as a Prevalent Source of Aldosterone Production in Primary Aldosteronism.American journal of hypertension · 2022Article
- Recalibrating Interpretations of Aldosterone Assays Across the Physiologic Range: Immunoassay and Liquid Chromatography-Tandem Mass Spectrometry Measurements Under Multiple Controlled Conditions.Journal of the Endocrine Society · 2022Article
- Adrenocorticotropic Hormone-Stimulated Adrenal Venous Sampling Underestimates Surgically Curable Primary Aldosteronism: A Retrospective Cohort Study and Review of Contemporary Studies.Hypertension (Dallas, Tex. : 1979) · 2021Review
- Repeat Adrenal Vein Sampling in Aldosteronism: Reproducibility and Interpretation of Persistently Discordant Results.The Journal of clinical endocrinology and metabolism · 2021Article
- Intraindividual Variability of Aldosterone Concentrations in Primary Aldosteronism: Implications for Case Detection.Hypertension (Dallas, Tex. : 1979) · 2021Article
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7 authors at 3 institutions in 2 countries.
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Abstract
backgroundVariability of aldosterone concentrations has been described in patients with primary aldosteronism.
methodsWe performed a retrospective cohort study of 340 patients with primary aldosteronism who underwent adrenal venous sampling (AVS) at a tertiary referral center, 116 of whom also had a peripheral venous aldosterone measured hours before the procedure. AVS was performed by the same interventional radiologist using bilateral, simultaneous sampling, under unstimulated and then stimulated conditions, and each sample was obtained in triplicate. Main outcome measures were: (i) change in day of AVS venous aldosterone from pre-AVS to intra-AVS and (ii) variability of triplicate adrenal venous aldosterone concentrations during AVS.
resultsWithin an average duration of 131 minutes, 81% of patients had a decline in circulating aldosterone concentrations (relative decrease of 51% and median decrease of 7.0 ng/dl). More than a quarter (26%) of all patients had an inferior vena cava aldosterone of ≤5 ng/dl at AVS initiation. The mean coefficient of variation of triplicate adrenal aldosterone concentrations was 30% and 39%, in the left and right veins, respectively (corresponding to a percentage difference of 57% and 73%), resulting in lateralization discordance in up to 17% of patients if the lateralization index were calculated using only one unstimulated aldosterone-to-cortisol ratio rather than the average of triplicate measures.
conclusionsCirculating aldosterone levels can reach nadirs conventionally considered incompatible with the primary aldosteronism diagnosis, and adrenal venous aldosterone concentrations exhibit acute variability that can confound AVS interpretation. A single venous aldosterone measurement lacks precision and reproducibility in primary aldosteronism.
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