Evidence map›Paper›PMID 33179621›Full record

ReviewPathologica2020

Celiac disease: histology-differential diagnosis-complications. A practical approach.

Vincenzo Villanacci, Alessandro Vanoli, Giuseppe Leoncini, Giovanni Arpa, Tiziana Salviato, Luca Reggiani Bonetti, Carla Baronchelli, Luca Saragoni, Paola Parente

Open access · diamondAbstract readReview
In one paragraph

Review in Pathologica, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 69 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Wheat-Related Gastrointestinal Diseases: Narrative Review.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2025
    Review
  8. Article
  9. Eating behaviors and mental health among celiac patients, case-control study.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2025
    Article
  10. Review
  11. Celiac Disease: Beyond Diet and Food Awareness.Foods (Basel, Switzerland) · 2025
    Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Observational
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Vincenzo VillanacciInstitute of Pathology, Spedali Civili di Brescia, Italy.
Alessandro VanoliAnatomic Pathology Unit, Department of Molecular Medicine, University of Pavia, Italy.
Giuseppe LeonciniPathology Unit, ASST del Garda, Desenzano del Garda, BS, Italy.
Giovanni ArpaAnatomic Pathology Unit, Department of Molecular Medicine, University of Pavia, Italy.
Tiziana SalviatoDepartment of Diagnostic, Clinic and Public Health Medicine, University of Modena and Reggio Emilia, Modena, Italy.
Luca Reggiani BonettiDepartment of Diagnostic, Clinic and Public Health Medicine, University of Modena and Reggio Emilia, Modena, Italy.
Carla BaronchelliInstitute of Pathology, Spedali Civili di Brescia, Italy.
Luca SaragoniDepartment of Pathological Anatomy, AUSL Romagna, Morgagni-Pierantoni Hospital, Forlì, Italy.
Paola ParentePathology Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, FG, Italy.
Istituti di Ricovero e Cura a Carattere Scientifico · ITAzienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · ITUniversity of Modena and Reggio Emilia · ITCasa di Cura Villa Garda · ITOspedale G.B. Morgagni - L.Pierantoni · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Celiac disease is a multi-factorial chronic inflammatory intestinal disease, characterized by malabsorption resulting from mucosal injury after ingestion of wheat gluten or related rye and barley proteins. Inappropriate T-cell-mediated immune response against ingested gluten in genetically predisposed people, leads to characteristic histological lesions, as villous atrophy and intraepithelial lymphocytosis. Nevertheless, celiac disease is a comprehensive diagnosis with clinical, serological and genetic characteristics integrated with histological features. Biopsy of duodenal mucosa remains the gold standard in the diagnosis of celiac disease with the recognition of the spectrum of histological changes and classification of mucosa damage based on updated Corazza-Villanacci system. Appropriate differential diagnosis evaluation and clinical context also for the diagnosis of complications is, moreover, needed for correct histological features interpretation and clinical management.

Indexed as

Celiac DiseaseBiopsyDiagnosis, DifferentialDuodenitisDuodenumGenetic Predisposition to DiseaseGlutensHumansIntestinal MucosaIntestine, SmallGlutensceliac diseaseglutensmall bowelsprue

Identifiers

PMID33179621
PMCPMC7931573
OpenAlexW3097413815

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.