Evidence map›Paper›PMID 33179616›Full record

ReviewPathologica2020

Gastro-esophageal reflux disease and Barrett's esophagus: an overview with an histologic diagnostic approach.

Luca Mastracci, Federica Grillo, Paola Parente, Elettra Unti, Serena Battista, Paola Spaggiari, Michela Campora, Giulia Scaglione, Matteo Fassan, Roberto Fiocca

Open access · diamondAbstract readReview
In one paragraph

Review in Pathologica, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Pathogenesis of Barrett's Esophagus: Evolving and Emerging Mechanisms.Gastrointestinal endoscopy clinics of North America · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Luca Mastracci *Anatomic Pathology, San Martino IRCCS Hospital, Genova, Italy.
Federica Grillo *Anatomic Pathology, San Martino IRCCS Hospital, Genova, Italy.
Paola ParenteUnit of Pathology, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, (FG), Italy.
Elettra UntiUOC Anatomia Patologica, ARNAS Ospedali Civico-Di Cristina-Benfratelli, Palermo, Italy.
Serena BattistaSOC di Anatomia Patologica, Azienda Sanitaria Universitaria Friuli Centrale, Udine, Italy.
Paola SpaggiariDepartment of Pathology, Humanitas Clinical and Research Center-IRCCS, Rozzano, Milan, Italy.
Michela CamporaAnatomic Pathology, San Martino IRCCS Hospital, Genova, Italy.
Giulia ScaglioneAnatomic Pathology, San Martino IRCCS Hospital, Genova, Italy.
Matteo FassanSurgical Pathology Unit, Department of Medicine (DIMED), University of Padua, Italy.
Roberto FioccaAnatomic Pathology, San Martino IRCCS Hospital, Genova, Italy.
Ospedale Policlinico San Martino · ITAzienda di Rilievo Nazionale ed Alta Specializzazione · ITAzienda Unità Sanitaria Locale di Ferrara · ITCasa Sollievo della Sofferenza · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITUniversity of Padua · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The first part of this overview on non-neoplastic esophagus is focused on gastro-esophageal reflux disease (GERD) and Barrett's esophagus. In the last 20 years much has changed in histological approach to biopsies of patients with gastro-esophageal reflux disease. In particular, elementary histologic lesions have been well defined and modality of evaluation and grade are detailed, their sensitivity and specificity has been evaluated and their use has been validated by several authors. Also if there is not a clinical indication to perform biopsies in patient with GERD, the diagnosis of microscopic esophagitis, when biopsies are provided, can be performed by following simple rules for evaluation which allow pathologists to make the diagnosis with confidence. On the other hand, biopsies are required for the diagnosis of Barrett's esophagus. This diagnosis is the synthesis of endoscopic picture (which has to be provided with the proper description on extent and with adequate biopsies number) and histologic pattern. The current guidelines and expert opinions for the correct management of these diagnosis are detailed.

Indexed as

Barrett EsophagusGastroesophageal RefluxBiopsyEsophageal NeoplasmsEsophagusHumansMetaplasiaPrecancerous ConditionsBarrett’s esophagusgastro-esophageal reflux disease (GERD)histologyintestinal metaplasia of the cardiamicroscopic esophagitis

Identifiers

PMID33179616
PMCPMC7931578
OpenAlexW3097756312

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.