Evidence map›Paper›PMID 33179612›Full record

ArticlePhysics in medicine and biology2020

Detective quantum efficiency of intensified CMOS cameras for Cherenkov imaging in radiotherapy.

Daniel A Alexander, Petr Bruza, J Cedar M Farwell, Venkat Krishnaswamy, Rongxiao Zhang, David J Gladstone, Brian W Pogue

Abstract read
In one paragraph

Article in Physics in medicine and biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Color Cherenkov imaging of clinical radiation therapy.Light, science & applications · 2021
    Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Daniel A AlexanderThayer School of Engineering, Dartmouth College, Hanover, NH 03755, United States of America.ORCID 0000-0003-3831-7479
Petr BruzaThayer School of Engineering, Dartmouth College, Hanover, NH 03755, United States of America.ORCID 0000-0002-6196-5872
J Cedar M FarwellDoseOptics LLC, Lebanon, NH 03766, United States of America.
Venkat KrishnaswamyDoseOptics LLC, Lebanon, NH 03766, United States of America.
Rongxiao ZhangThayer School of Engineering, Dartmouth College, Hanover, NH 03755, United States of America.ORCID 0000-0002-0423-7828
David J GladstoneThayer School of Engineering, Dartmouth College, Hanover, NH 03755, United States of America.
Brian W PogueThayer School of Engineering, Dartmouth College, Hanover, NH 03755, United States of America.ORCID 0000-0002-9887-670X

Funding

Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Fred W Kolling IV · 1985 to 2026
$91.3M
OPTICAL CHERENKOV IMAGING DOSIMETRY IN HUMAN RADIOTHERAPYR01EB023909 · NIBIB · UNIVERSITY OF WISCONSIN-MADISON · PI GLADSTONE, DAVID J., JARVIS, LESLEY A · 2017 to 2024
$4.4M
Video Rate optical verification tool for radiotherapy treatment plansR44CA199681 · NCI · DOSEOPTICS, LLC · PI WARE, WILLIAM · 2016 to 2017
$2.0M
NCI NIH HHS P30 CA023108NCI NIH HHS R44 CA199681NIBIB NIH HHS R01 EB023909
6 · The paper itself

Abstract

In this study the metric of detective quantum efficiency (DQE) was applied to Cherenkov imaging systems for the first time, and results were compared for different detector hardware, gain levels and with imaging processing for noise suppression. Intensified complementary metal oxide semiconductor cameras using different image intensifier designs (Gen3 and Gen2+) were used to image Cherenkov emission from a tissue phantom in order to measure the modulation transfer function (MTF) and noise power spectrum (NPS) of the systems. These parameters were used to calculate the DQE for varying acquisition settings and image processing steps. MTF curves indicated that the Gen3 system had superior contrast transfer and spatial resolution than the Gen2+ system, with [Formula: see text] values of 0.52 mm

Indexed as

Quantum TheoryRadiotherapy, Image-GuidedSemiconductorsImage Processing, Computer-AssistedMetalsOxidesPhantoms, ImagingMetalsOxides

Identifiers

PMID33179612
PMCPMC10416224

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.