ArticleInhalation toxicology
Urinary levels of the acrolein conjugates of carnosine are associated with inhaled toxicants.
Article in Inhalation toxicology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 4 citations in OpenAlex.
- Comparative evaluation of different modalities for measuring in vivo carnosine levels.PloS one · 2024Article
- Urinary Levels of the Acrolein Conjugates of Carnosine Are Associated with Cardiovascular Disease Risk.International journal of molecular sciences · 2021Observational
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThe inhalation of air-borne toxicants is associated with adverse health outcomes which can be somewhat mitigated by enhancing endogenous anti-oxidant capacity. Carnosine is a naturally occurring dipeptide (β-alanine-L-histidine), present in high abundance in skeletal and cardiac muscle. This multi-functional dipeptide has anti-oxidant properties, can buffer intracellular pH, chelate metals, and sequester aldehydes such as acrolein. Due to these chemical properties, carnosine may be protective against inhaled pollutants which can contain metals and aldehydes and can stimulate the generation of electrophiles in exposed tissues. Thus, assessment of carnosine levels, or levels of its acrolein conjugates (carnosine-propanal and carnosine-propanol) may inform on level of exposure and risk assessment.
methodsWe used established mass spectroscopy methods to measure levels of urinary carnosine (
resultsWe found that higher levels of non-conjugated carnosine, carnosine-propanal, and carnosine-propanol were significantly associated with males (
conclusionsThese findings suggest that urinary levels of carnosine-propanol may inform as to risk from inhaled pollutants.
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Registered trials
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