Evidence map›Paper›PMID 33179489›Full record

ArticleJournal of the American Chemical Society2020

Aryl Amination Using Soluble Weak Base Enabled by a Water-Assisted Mechanism.

Sii Hong Lau, Peng Yu, Liye Chen, Christina B Madsen-Duggan, Michael J Williams, Brad P Carrow

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 34 citations in OpenAlex.

  1. Base-Free C-N Cross-Electrophile Coupling.Journal of the American Chemical Society · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Sii Hong LauDepartment of Chemistry, Princeton University, Princeton, New Jersey 08544, United States.
Peng YuDepartment of Chemistry, Princeton University, Princeton, New Jersey 08544, United States.
Liye ChenDepartment of Chemistry, Princeton University, Princeton, New Jersey 08544, United States.
Christina B Madsen-DugganChemical Process Development, Bristol Myers Squibb, 556 Morris Avenue, Summit, New Jersey 07902, United States.
Michael J WilliamsChemical Process Development, Bristol Myers Squibb, 556 Morris Avenue, Summit, New Jersey 07902, United States.
Brad P CarrowDepartment of Chemistry, Princeton University, Princeton, New Jersey 08544, United States.ORCID 0000-0003-4929-8074
Princeton University · USBristol-Myers Squibb (United States) · US

Funding

Aliphatic Effects in Transition Metal CatalysisR35GM128902 · NIGMS · UNIVERSITY OF HOUSTON · PI CARROW, BRADLEY · 2018 to 2022
$1.9M
NIGMS NIH HHS R35 GM128902
6 · The paper itself

Abstract

The amination of aryl halides has become one of the most commonly practiced C-N bond-forming reactions in pharmaceutical and laboratory syntheses. The widespread use of strong or poorly soluble inorganic bases for amine activation nevertheless complicates the compatibility of this important reaction class with sensitive substrates as well as applications in flow and automated synthesis, to name a few. We report a palladium-catalyzed C-N coupling using Et

Indexed as

AminationAminesCarbonCatalysisLigandsNitrogenPalladiumWaterAminesCarbonLigandsNitrogenPalladiumWater

Identifiers

PMID33179489
PMCPMC7690001
OpenAlexW3098044317

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.