Evidence map›Paper›PMID 33179341›Full record

ArticleClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology2021

The epidemiology of eczema in children and adults in England: A population-based study using primary care data.

Simon de Lusignan, Helen Alexander, Conor Broderick, John Dennis, Andrew McGovern, Claire Feeney, Carsten Flohr

Open access · hybridAbstract read
In one paragraph

Article in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 4 pooled it
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 4 syntheses or guidelines pooled it, 86 citations in OpenAlex.

  1. Topical Anti-Inflammatory Treatments for Eczema: A Cochrane Systematic Review and Network Meta-Analysis.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2024
    Pooled it
  2. Topical anti-inflammatory treatments for eczema: network meta-analysis.The Cochrane database of systematic reviews · 2024
    Pooled it
  3. Pooled it
  4. Phototherapy for atopic eczema.The Cochrane database of systematic reviews · 2021
    Pooled it
  5. Review
  6. Atopic dermatitis is associated with herpes zoster in adults - A matched cohort study using electronic health records data in England.Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG · 2026
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  14. Observational
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  16. IL-31/33 Axis in Atopic Dermatitis.International journal of molecular sciences · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Simon de LusignanNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
Helen AlexanderUnit for Population-Based Dermatology Research, St John's Institute of Dermatology, Guy's & Thomas' NHS Foundation Trust and King's College London, London, UK.
Conor BroderickUnit for Population-Based Dermatology Research, St John's Institute of Dermatology, Guy's & Thomas' NHS Foundation Trust and King's College London, London, UK.
John DennisMomentum Data, Pendragon House, St. Albans, UK.
Andrew McGovernMomentum Data, Pendragon House, St. Albans, UK.
Claire FeeneyPfizer Ltd, Tadworth, UK.
Carsten FlohrUnit for Population-Based Dermatology Research, St John's Institute of Dermatology, Guy's & Thomas' NHS Foundation Trust and King's College London, London, UK.ORCID 0000-0003-4884-6286
King's College London · GBMomentum (United Kingdom) · GBPfizer (United Kingdom) · GBUniversity of Oxford · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWhilst eczema is a common inflammatory skin condition, we lack contemporary estimates of disease incidence and prevalence across the lifespan.

objectiveTo estimate the incidence and prevalence of eczema in children and adults in England and variation by sociodemographic factors (sex, socio-economic status, ethnicity, and geography).

methodsWe used the Royal College of General Practitioners Research and Surveillance Centre primary care research database of 3.85 million children and adults registered with participating general practitioner practices between 2009 and 2018 inclusive. Eczema incidence was defined as the first-ever diagnosis of eczema recorded in the primary care record, and eczema prevalence was defined as fulfilment of criteria for active eczema (two eczema records appearing in the primary care record within any one-year period).

resultsEczema incidence was highest in infants younger than 1 year (15.0 per 100 person-years), lowest in adults aged 40-49 (0.35 p/100 person-years), and increased from middle age to a second smaller peak in people 80 years or older (0.79 p/100 person-years). Eczema prevalence was highest in children aged 2 (16.5%) and lowest in adults aged 30-39 (2.8%). Eczema incidence was higher in male infants (<2) and male adults older than 70; for all other ages, incidence was higher in females. Eczema was more common in Asian and black ethnic groups than in people of white ethnicity. Higher socio-economic status was associated with a greater incidence of eczema in infants younger than 2, but the reverse was seen for all other age groups. Both incidence and prevalence of eczema were greater in urban settings and in North-West England. CONCLUSIONS AND CLINICAL RELEVANCE: Eczema has a bimodal distribution across the lifespan. We observed differences in incidence and prevalence of eczema by ethnicity, geography, sex, and socio-economic status, which varied in magnitude throughout life.

Indexed as

AdolescentAdultAgedAged, 80 and overAge DistributionChildChild, PreschoolDermatitis, AtopicEnglandFemaleHumansIncidenceInfantInfant, NewbornMaleMiddle Agedatopic dermatitisdermatologyeczemaepidemiologyincidenceprimary care

Identifiers

PMID33179341
PMCPMC7984097
OpenAlexW3103581677

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.