Evidence map›Paper›PMID 33179158›Full record

ArticleMolecular imaging and biology2021

Kinetic Modelling and Test-Retest Reproducibility for the Dopamine D

Daniele Bertoglio, Jeroen Verhaeghe, Alan Miranda, Leonie Wyffels, Sigrid Stroobants, Celia Dominguez, Ignacio Munoz-Sanjuan, Mette Skinbjerg, Longbin Liu, Steven Staelens

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular imaging and biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 7 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Daniele BertoglioMolecular Imaging Center Antwerp (MICA), University of Antwerp, Wilrijk, Belgium.ORCID http://orcid.org/0000-0003-4205-5432
Jeroen VerhaegheMolecular Imaging Center Antwerp (MICA), University of Antwerp, Wilrijk, Belgium.
Alan MirandaMolecular Imaging Center Antwerp (MICA), University of Antwerp, Wilrijk, Belgium.
Leonie WyffelsMolecular Imaging Center Antwerp (MICA), University of Antwerp, Wilrijk, Belgium.
Sigrid StroobantsMolecular Imaging Center Antwerp (MICA), University of Antwerp, Wilrijk, Belgium.
Celia DominguezCHDI Management/CHDI Foundation, Los Angeles, CA, USA.
Ignacio Munoz-SanjuanCHDI Management/CHDI Foundation, Los Angeles, CA, USA.
Mette SkinbjergCHDI Management/CHDI Foundation, Los Angeles, CA, USA.
Longbin LiuCHDI Management/CHDI Foundation, Los Angeles, CA, USA.
Steven StaelensMolecular Imaging Center Antwerp (MICA), University of Antwerp, Wilrijk, Belgium. steven.staelens@uantwerpen.be.
University of Antwerp · BECHDI Foundation · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeOur aim in this study was to compare different non-invasive pharmacokinetic models and assess test-retest reproducibility of the radioligand [ PROCEDURES: Adult WT (n = 9) and HET (n = 14) mice underwent a 90-min [

resultsFor all models, we measured a significant decline in dopamine D

conclusionsNinety-minute acquisition and the use of SRTM for pharmacokinetic modelling is recommended. [

Indexed as

AnimalsBenzazepinesBrainCarbon RadioisotopesDisease Models, AnimalGene Knock-In TechniquesHuntington DiseaseMaleMiceMice, TransgenicMolecular ImagingPositron-Emission TomographyReceptors, Dopamine D1Reproducibility of ResultsTissue DistributionBenzazepinesCarbon-11Carbon RadioisotopesReceptors, Dopamine D1SCH 23390D1RDopamine receptorHuntington’s diseaseKinetic modellingMousePreclinical imagingQ175DNSCH23390Test-retest

Identifiers

PMID33179158
PMCPMC7910372
OpenAlexW3101919504

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.