Evidence map›Paper›PMID 33179150›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2021

Development of [

Anchal Ghai, Alexander Zheleznyak, Matt Mixdorf, Julie O'Neal, Julie Ritchey, Michael Rettig, John DiPersio, Monica Shokeen, Samuel Achilefu

Open access · greenAbstract read
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Selective PET imaging of CXCR4 using the AlEuropean journal of nuclear medicine and molecular imaging · 2025
    Article
  5. Development of a [89Zr]Zr-labeled Human Antibody using a Novel Phage-displayed Human scFv Library.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024
    Article
  6. Single-Domain Antibody Theranostics on the Horizon.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Anchal GhaiDepartment of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
Alexander ZheleznyakDepartment of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
Matt MixdorfDepartment of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
Julie O'NealDepartment of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Julie RitcheyDepartment of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Michael RettigDepartment of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
John DiPersioDepartment of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Monica ShokeenDepartment of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
Samuel AchilefuDepartment of Radiology, Washington University School of Medicine, St. Louis, MO, USA. achilefu@wustl.edu.ORCID http://orcid.org/0000-0002-3133-6717
Washington University in St. Louis · US

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI AIMEE S JAMES · 2001 to 2026
$128.0M
TrainingP41GM103422 · NIGMS · WASHINGTON UNIVERSITY · PI YARASHESKI, KEVIN E · 2012 to 2019
$12.0M
Project 2 - Radiation-Induced Treatment of Multiple Myeloma using NanoparticlesU54CA199092 · NCI · WASHINGTON UNIVERSITY · PI PRIOR, FRED WILLIAM · 2015 to 2019
$11.5M
Exploring CD38 molecular biology and imaging in multiple myeloma pathogenesisR01CA248493 · NCI · WASHINGTON UNIVERSITY · PI SHOKEEN, MONICA · 2020 to 2024
$3.1M
NANOPHOTOSENSITIZERS FOR REGENERATIVE PHOTOTHERAPY OF TUMORSR01EB021048 · NIBIB · WASHINGTON UNIVERSITY · PI ACHILEFU, SAMUEL · 2015 to 2020
$2.3M
BM NICHE DISRUPTION AND IMMUNOTHERAPY IN HEMATOLOGICAL MALIGNANCIESR50CA211466 · NCI · WASHINGTON UNIVERSITY · PI Michael Rettig · 2016 to 2026
$2.3M
IVIS Spectrum CT Preclinical In Vivo Imaging SystemS10OD027042 · OD · WASHINGTON UNIVERSITY · PI ACHILEFU, SAMUEL · 2019 to 2019
$599k
Multispectral Optoacoustic Tomography (MSOT) SystemS10OD025264 · OD · WASHINGTON UNIVERSITY · PI ACHILEFU, SAMUEL · 2018 to 2018
$544k
FLUORESCENCE MOLECULAR TOMOGRAPHY SYSTEMS10OD020129 · OD · WASHINGTON UNIVERSITY · PI ACHILEFU, SAMUEL · 2015 to 2015
$330k
NCI NIH HHS P30 CA091842NCI NIH HHS R01 CA248493NCI NIH HHS R50 CA211466NCI NIH HHS U54 CA199092NIBIB NIH HHS R01 EB021048NIGMS NIH HHS P41 GM103422NIH HHS S10 OD020129NIH HHS S10 OD025264NIH HHS S10 OD027042
6 · The paper itself

Abstract

purposeMultiple myeloma (MM) is a bone marrow malignancy that remains mostly incurable. Elotuzumab is an FDA-approved therapeutic monoclonal antibody targeted to the cell surface glycoprotein CS1, which is overexpressed in MM cells. Identifying patients who will respond to CS1-targeted treatments such as elotuzumab requires the development of a companion diagnostic to assess the presence of CS1. Here, we evaluated [

methodsConjugation of desferrioxamine-p-benzyl-isothiocyanate (DFO-Bz-NCS) to elotuzumab enabled zirconium-89 radiolabeling. MM.1S-CG cells were intravenously injected in NOD SCID gamma (NSG) mice. Small animal PET imaging with [

results[

conclusionThese data demonstrate the feasibility of [

Indexed as

Multiple MyelomaAnimalsAntibodies, Monoclonal, HumanizedCell Line, TumorHumansMiceMice, SCIDPositron-Emission TomographyTissue DistributionZirconiumAntibodies, Monoclonal, HumanizedelotuzumabZirconium[89Zr]DFO-elotuzumabCS1 antigenMultiple myelomaPET imaging

Identifiers

PMID33179150
PMCPMC8110592
OpenAlexW3106048667

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.