ArticleRheumatology (Oxford, England)2021
Clinical course of 602 patients with Takayasu's arteritis: comparison between Childhood-onset versus adult onset disease.
Article in Rheumatology (Oxford, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 3 of them syntheses that pooled it.
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Who cites it
35 citing papers in PubMed, 3 syntheses or guidelines pooled it, 84 citations in OpenAlex.
- Prevalence and clinical severity of takayasu arteritis angiographic types: a systematic review with meta-analysis.Rheumatology international · 2025Pooled it
- A Systematic Review of Anti-TNF and Anti-IL-6 Treatments for Pediatric Takayasu Arteritis: Addressing a Therapeutic Dilemma.Paediatric drugs · 2025Pooled it
- Real-World Biomarkers for Pediatric Takayasu Arteritis.International journal of molecular sciences · 2024Pooled it
- Cutaneous Pediatric Vasculitis: A Clinico-Histopathological Overview of Common and Novel Entities.Dermatopathology (Basel, Switzerland) · 2026Review
- Neurological Complications in Pediatric Takayasu Arteritis: Insights from a Single-Center Experience.Journal of clinical medicine · 2026Article
- Age specific clinical manifestations and vascular involvements in childhood-onset Takayasu arteritis.Pediatric research · 2026Article
- Clinical characteristics and vascular involvement of Takayasu arteritis versus Kawasaki disease in infants and young children.Pediatric rheumatology online journal · 2026Article
- Article
- Advances in the pathophysiology, diagnosis and treatment of Takayasu arteritis.Nature reviews. Rheumatology · 2025Review
- Clinical profile and long-term outcomes of pediatric-onset Takayasu's arteritis: data from a mexican national referral center.Pediatric rheumatology online journal · 2025Article
- Childhood-onset Takayasu arteritis: clinical presentation, challenges and disease course.Pediatric rheumatology online journal · 2025Article
- A retrospective cohort study of 203 patients with Takayasu arteritis: experience from a Brazilian tertiary center.Advances in rheumatology (London, England) · 2025Article
- IgG4-related disease and other fibro-inflammatory conditions.Nature reviews. Rheumatology · 2025Review
- Positron Emission Tomography in Takayasu Arteritis: A Review Including Patterns of Vascular Involvement Across Modalities and Regions.Journal of clinical medicine · 2025Review
- Differentiating Between Fibromuscular Dysplasia and Takayasu Arteritis in a Patient With Juvenile Renovascular Hypertension and Marked Hypokalemia Effectively Treated With Percutaneous Transluminal Renal Angioplasty.Journal of clinical medicine research · 2025Article
- Childhood-Onset Takayasu Arteritis: Clinical Features of Disease and Relapse Risk Factors.Children (Basel, Switzerland) · 2025Article
- An uncommon cause of a common disease: a case report of a rare cause of hypertension.European heart journal. Case reports · 2024Article
- Clinical Characteristics of Patients with Takayasu Arteritis Undergoing Open or Endovascular Operations in China.Reviews in cardiovascular medicine · 2024Article
- A Glimpse into Humoral Response and Related Therapeutic Approaches of Takayasu's Arteritis.International journal of molecular sciences · 2024Review
- Chinese guideline for the diagnosis and treatment of Takayasu's arteritis (2023).Rheumatology and immunology research · 2024Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo describe the clinical profile of Asian Indian patients with Takayasu's arteritis (TAK) and to compare clinical features and outcome of childhood-onset Takayasu's arteritis (cTAK) with adult-onset TAK (aTAK).
methodsData related to clinical features and response to treatment of patients with cTAK (age of onset <16 years) and aTAK from a large observational cohort in our tertiary care teaching hospital were noted and compared.
resultsAltogether, 602 patients (cTAK = 119; aTAK = 483) were studied. Patients with cTAK had a blunted female: male ratio; but fever, elevated acute phase reactants, involvement of abdominal aorta or its branches, hypertension, abdominal pain, elevated serum creatinine and cardiomyopathy were more common in cTAK as compared with aTAK. Patients with aTAK were more likely to have aortic-arch disease and claudication than cTAK. During follow-up, complete remission was more common in cTAK (87% vs 66%; P < 0.01), but subsequent relapses were equally common (30% vs 27%; P = 0.63). Independent associations of disease duration at presentation with disease extent [Disease Extent Index in TAK (DEI.Tak)] and damage [TAK Damage Score (TADS)] were observed (P ≤ 0.01). Moreover, 54% of patients with symptom duration of >5 years at presentation still continued to have elevated CRP suggesting continued and active inflammation warranting escalation or inititation of immunosuppression.
conclusionPatients with cTAK are more likely to have arterial disease below the diaphragm, systemic inflammation and achieve remission. Disease of the aortic arch is more common in patients with aTAK. Longer duration of symptoms prior to initiation of immunosuppression, thereby leading to extensive disease and damage, reflects ongoing disease activity as the rule rather than exception in untreated TAK.
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