Evidence map›Paper›PMID 33178931›Full record

ArticleBJR open2019

Differences in degree of lesion enhancement on CEM between ILC and IDC.

Thiemo Ja van Nijnatten, Maxine S Jochelson, Katja Pinker, Delia M Keating, Janice S Sung, Monica Morrow, Marjolein L Smidt, Marc Bi Lobbes

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BJR open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 3 countries.

Thiemo Ja van NijnattenORCID 0000-0002-6431-3538
Maxine S JochelsonDepartment of Radiology, Breast Imaging Service, Memorial Sloan-Kettering Cancer Center, New York, USA.
Katja Pinker
Delia M KeatingDepartment of Radiology, Breast Imaging Service, Memorial Sloan-Kettering Cancer Center, New York, USA.
Janice S SungDepartment of Radiology, Breast Imaging Service, Memorial Sloan-Kettering Cancer Center, New York, USA.
Monica MorrowDepartment of Surgery, Memorial Sloan-Kettering Cancer Center, New York, USA.
Marjolein L Smidt
Marc Bi Lobbes
Memorial Sloan Kettering Cancer Center · USMaastricht University · NL

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

objectiveTo investigate differences in the degree of enhancement on contrast-enhanced mammography (CEM) between patients with invasive lobular (ILC) and infiltrating ductal carcinoma (IDC) not otherwise specified. METHODS AND MATERIALS: Between 2010 and 2017, all patients diagnosed with ILC and who underwent CEM were included for this dual center study. Twenty-two patients with IDC, matched by size, were identified for comparison. Three independent readers, blinded for histopathology results, re-evaluated all CEM exams to determine degree of lesion enhancement according to a previously defined scoring scale ranging from minimal to strong enhancement. Interobserver agreement among the three readers was calculated by quadratic weighted κ coefficient.

results44 patients were included: 22 patients with ILC and 22 patients with IDC. There were no significant differences in age, mean tumor size, tumor grade or receptor status between the two subgroups. Degree of lesion enhancement on CEM was more often considered weak in case of ILC compared to IDC according to two out of three readers (31.8%

conclusionIn patients with ILC, degree of lesion enhancement on CEM appears to be more often weak than in infiltrating ductal carcinoma not otherwise specified. Radiologists should be aware that weakly enhancing lesions may in fact be malignant and particularly invasive lobular cancers. ADVANCES IN KNOWLEDGE: Three independent readers evaluated 44 CEM cases with ILC or IDC. Degree of lesion enhancement seems more often weak in case of ILC. Radiologists should be aware of ILC in case of weak CEM enhancement.

Identifiers

PMID33178931
PMCPMC7592434
OpenAlexW2921077177

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.