Evidence map›Paper›PMID 33178896›Full record

ArticleTrauma surgery & acute care open2020

Initial clinical experience with the Quantra QStat System in adult trauma patients.

Edward A Michelson, Michael W Cripps, Bradford Ray, Deborah A Winegar, Francesco Viola

Open access · goldAbstract read
In one paragraph

Article in Trauma surgery & acute care open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.7field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 28 citations in OpenAlex.

  1. SEER sonorheometry enhances fibrinolysis detection during liver transplantation with heparin.Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis · 2026
    Article
  2. Review
  3. Baseline values for QuantraBMC pregnancy and childbirth · 2025
    Observational
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. The Quantra System: System Description and Protocols for Measurements.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
  11. Review
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Edward A MichelsonTexas Tech University Health Sciences Center El Paso, El Paso, Texas, USA.
Michael W CrippsUniversity of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA.
Bradford RayUniversity Medical Center of El Paso, El Paso, Texas, USA.
Deborah A WinegarHemoSonics LLC, Charlottesville, Virginia, USA.
Francesco ViolaHemoSonics LLC, Charlottesville, Virginia, USA.
HemoSonics (United States) · USTexas Tech University · USThe University of Texas Southwestern Medical Center · USUniversity Medical Center of El Paso · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWhole blood viscoelastic testing (VET) devices are routinely used in a variety of clinical settings to assess hemostasis. The Quantra QStat System is a cartridge-based point of care VET device that measures changes in clot stiffness during coagulation and fibrinolysis using ultrasound detection of resonance. The objective of this study was to assess the ability of the Quantra QStat System to detect coagulopathies in trauma patients.

methodsA multicenter observational study was conducted on adult subjects at two level 1 trauma centers. For each subject, whole blood samples were drawn upon arrival to the emergency department and again, in some cases, after administration of blood products and/or antifibrinolytics. Samples were analyzed on the Quantra in parallel to ROTEM

resultsA total of 56 patients were analyzed. 42% of samples had a low QStat CS value suggestive of an hypocoagulable state. The low stiffness values could be attributed to either low PCS, FCS or combination. Additionally, 13% of samples showed evidence of hyperfibrinolysis based on the QStat CSL parameter. Samples analyzed with ROTEM assays showed a lower prevalence of low CS and hyperfibrinolysis based on EXTEM and FIBTEM results. The correlation of CS, FCS and CT versus equivalent ROTEM parameters was strong with r-values of 0.83, 0.79 and 0.79, respectively. DISCUSSION: This first clinical experience with the Quantra in trauma patients showed that the QStat Cartridge was strongly correlated with ROTEM parameters and that it could detect coagulopathies associated with critical bleeding. LEVEL OF EVIDENCE: Diagnostic test, Level II.

Indexed as

blood coagulationblood coagulation testsfibrinolysishemorrhage

Identifiers

PMID33178896
PMCPMC7640591
OpenAlexW3095748190

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.