ReviewAnnals of translational medicine2020
Brain imaging biomarkers of carotid artery disease.
Review in Annals of translational medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 24 citations in OpenAlex.
- Carotid intraplaque neovascularization and cerebral microbleeds: correlation assessed by plane-wave ultrasensitive flow imaging.Frontiers in neurology · 2026Article
- Research on ischemic stroke risk assessment based on CTA radiomics and machine learning.BMC medical imaging · 2025Article
- Machine learning using scRNA-seq Combined with bulk-seq to identify lactylation-related hub genes in carotid arteriosclerosis.Scientific reports · 2025Article
- Multiscale optoacoustic assessment of skin microvascular reactivity in carotid artery disease.Photoacoustics · 2024Article
- Diagnostic accuracy of superb microvascular imaging for detecting intraplaque neovascularization: a systematic review and meta-analysis.Cardiovascular diagnosis and therapy · 2023Article
- Advances in Noninvasive Carotid Wall Imaging with Ultrasound: A Narrative Review.Journal of clinical medicine · 2022Review
- Diagnostic and prognostic significance of lncRNA SOX2-OT in patients with carotid atherosclerosis.BMC cardiovascular disorders · 2022Article
- Hemodynamic MRI parameters to predict asymptomatic unilateral carotid artery stenosis with random forest machine learning.Frontiers in neuroimaging · 2022Article
- Identification of Biomarkers of Autophagy-Related Genes Between Early and Advanced Carotid Atherosclerosis.International journal of general medicine · 2022Article
- Extracranial carotid atherosclerosis is associated with increased neurofibrillary tangle accumulation.Journal of vascular surgery · 2022Observational
- Cerebral Small Vessel Disease Burden Related to Carotid Intraplaque Hemorrhage Serves as an Imaging Marker for Clinical Symptoms in Carotid Stenosis.Frontiers in neurology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Extracranial carotid artery atherosclerotic disease is a major contributor to ischemic stroke. Carotid atherosclerotic disease can present with a spectrum of findings ranging from mild carotid intima-media thickness to high-risk vulnerable carotid plaque features and carotid stenosis. Before leading to clinically overt stroke or transient ischemic attack, there may be other markers of downstream ischemia secondary to carotid atherosclerotic disease. In this review article, we will review some of the imaging findings that may be seen downstream to carotid artery disease on various imaging modalities, including hemodynamic and perfusional abnormalities which may be seen on CT, MR, or using other advanced imaging techniques, white matter hyperintensities on brain imaging, silent or covert brain infarctions, cerebral microbleeds, and regional and generalized cerebral volume loss. Many of these imaging findings are seen routinely on brain magnetic resonance imaging in patients without overt clinical symptoms. Despite frequently being asymptomatic, many of these imaging findings are also strongly associated with increased risk of future stroke, cognitive impairment, and even mortality. We will review the existing evidence underpinning the associations between these frequently encountered imaging findings and carotid artery atherosclerotic disease. Future validation of these imaging findings could lead to them being powerful biomarkers of cerebrovascular health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.