ArticleFrontiers in oncology2020
A Deep Learning Approach Validates Genetic Risk Factors for Late Toxicity After Prostate Cancer Radiotherapy in a REQUITE Multi-National Cohort.
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Article in Frontiers in oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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19citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 11% of its field
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- The Role of Artificial Intelligence in the Characterization and Outcome Prediction of Prostate Cancer: A Systematic Review.Tomography (Ann Arbor, Mich.) · 2026Pooled it
- Novel method for risk stratification of radiation-induced breast fibrosis: subgroup hypothesis verified by machine learning.NPJ breast cancer · 2026Article
- Genetic determinants of fatigue up to 2 years after radiotherapy in prostate cancer patients.Nature communications · 2026Article
- Voxel-Based Dose-Toxicity Modeling for Predicting Post-Radiotherapy Toxicity: A Critical Perspective.Journal of clinical medicine · 2025Article
- Risk factors for rectal bleeding in prostate cancer after radiotherapy with a validation of current rectal dose constraints.Acta oncologica (Stockholm, Sweden) · 2025Article
- Predictive Model of Acute Rectal Toxicity in Prostate Cancer Treated With Radiotherapy.JCO clinical cancer informatics · 2025Article
- Towards Personalized Radiotherapy in Pelvic Cancer: Patient-Related Risk Factors for Late Radiation Toxicity.Current oncology (Toronto, Ont.) · 2025Review
- Deep learning combining imaging, dose and clinical data for predicting bowel toxicity after pelvic radiotherapy.Physics and imaging in radiation oncology · 2025Article
- Data Science Opportunities To Improve Radiotherapy Planning and Clinical Decision Making.Seminars in radiation oncology · 2024Review
- Machine learning in onco-pharmacogenomics: a path to precision medicine with many challenges.Frontiers in pharmacology · 2023Review
- Article
- Investigation of the physiological response of radiation-induced cystitis patients using hyperbaric oxygen.Clinical and translational radiation oncology · 2023Article
- The Normal, the Radiosensitive, and the Ataxic in the Era of Precision Radiotherapy: A Narrative Review.Cancers · 2022Review
- Association of polymorphisms in TGFB1, XRCC1, XRCC3 genes and CD8 T-lymphocyte apoptosis with adverse effect of radiotherapy for prostate cancer.Scientific reports · 2022Article
- Efficient feature extraction from highly sparse binary genotype data for cancer prognosis prediction using an auto-encoder.Frontiers in oncology · 2022Article
- Development of a method for generating SNP interaction-aware polygenic risk scores for radiotherapy toxicity.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2021Article
- Biological Adaptations of Tumor Cells to Radiation Therapy.Frontiers in oncology · 2021Review
- The sex-dependent impact of PER2 polymorphism on sleep and activity in a novel mouse model of cranial-irradiation-induced hypersomnolence.Neuro-oncology advancesArticle
- A Ten-year-long Update on Radiation Proctitis Among Prostate Cancer Patients Treated With Curative External Beam Radiotherapy.In vivo (Athens, Greece)Review
Corrections and comments
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Authors and funding
46 authors at 20 institutions in 8 countries.
Michela Carlotta MassiModelling and Scientific Computing Laboratory, Math Department, Politecnico di Milano, Milan, Italy.
Francesca GasperoniMedical Research Council-Biostatistic Unit, University of Cambridge, Cambridge, United Kingdom.
Francesca IevaModelling and Scientific Computing Laboratory, Math Department, Politecnico di Milano, Milan, Italy.
Anna Maria PaganoniModelling and Scientific Computing Laboratory, Math Department, Politecnico di Milano, Milan, Italy.
Paolo ZuninoModelling and Scientific Computing Laboratory, Math Department, Politecnico di Milano, Milan, Italy.
Andrea ManzoniModelling and Scientific Computing Laboratory, Math Department, Politecnico di Milano, Milan, Italy.
Nicola Rares FrancoModelling and Scientific Computing Laboratory, Math Department, Politecnico di Milano, Milan, Italy.
Liv VeldemanDepartment of Human Structure and Repair, Ghent University, Ghent, Belgium.
Piet OstDepartment of Human Structure and Repair, Ghent University, Ghent, Belgium.
Valérie FonteyneDepartment of Human Structure and Repair, Ghent University, Ghent, Belgium.
Christopher J TalbotLeicester Cancer Research Centre, Department of Genetics and Genome Biology, University of Leicester, Leicester, United Kingdom.
Tim RattayLeicester Cancer Research Centre, Department of Genetics and Genome Biology, University of Leicester, Leicester, United Kingdom.
Adam WebbLeicester Cancer Research Centre, Department of Genetics and Genome Biology, University of Leicester, Leicester, United Kingdom.
Paul R SymondsLeicester Cancer Research Centre, Department of Genetics and Genome Biology, University of Leicester, Leicester, United Kingdom.
Kerstie JohnsonLeicester Cancer Research Centre, Department of Genetics and Genome Biology, University of Leicester, Leicester, United Kingdom.
Maarten LambrechtDepartment of Radiation Oncology, University Hospitals Leuven, Leuven, Belgium.
Karin HaustermansDepartment of Radiation Oncology, University Hospitals Leuven, Leuven, Belgium.
Gert De MeerleerDepartment of Radiation Oncology, University Hospitals Leuven, Leuven, Belgium.
Dirk de RuysscherMaastricht University Medical Center, Maastricht, Netherlands.
Ben VannesteDepartment of Radiation Oncology (Maastro), GROW Institute for Oncology and Developmental Biology, Maastricht, Netherlands.
Evert Van LimbergenMaastricht University Medical Center, Maastricht, Netherlands.
Ananya ChoudhuryTranslational Radiobiology Group, Division of Cancer Sciences, Manchester Academic Health Science Centre, Christie Hospital, University of Manchester, Manchester, United Kingdom.
Rebecca M ElliottTranslational Radiobiology Group, Division of Cancer Sciences, Manchester Academic Health Science Centre, Christie Hospital, University of Manchester, Manchester, United Kingdom.
Elena SperkDepartment of Radiation Oncology, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Carsten HerskindDepartment of Radiation Oncology, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Marlon R VeldwijkDepartment of Radiation Oncology, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Barbara AvuzziDepartment of Radiation Oncology 1, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Tommaso GiandiniDepartment of Medical Physics, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Riccardo ValdagniDepartment of Radiation Oncology 1, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Alessandro CicchettiProstate Cancer Program, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
David AzriaDepartment of Radiation Oncology, University Federation of Radiation Oncology, Montpellier Cancer Institute, Univ Montpellier MUSE, Grant INCa_Inserm_DGOS_12553, Inserm U1194, Montpellier, France.
Marie-Pierre Farcy JacquetDepartment of Radiation Oncology, University Federation of Radiation Oncology, CHU Caremeau, Nîmes, France.
Barry S RosensteinDepartment of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Richard G StockDepartment of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Kayla ColladoDepartment of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Ana VegaFundación Pública Galega de Medicina Xenómica, Grupo de Medicina Xenómica (USC), Santiago de Compostela, Spain.
Miguel Elías Aguado-BarreraFundación Pública Galega de Medicina Xenómica, Grupo de Medicina Xenómica (USC), Santiago de Compostela, Spain.
Patricia CalvoInstituto de Investigación Sanitaria de Santiago de Compostela, Santiago de Compostela, Spain.
Alison M DunningStrangeways Research Labs, Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom.
Laura FachalStrangeways Research Labs, Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom.
Sarah L KernsDepartments of Radiation Oncology and Surgery, University of Rochester Medical Center, Rochester, New York, NY, United States.
Debbie PayneCentre for Integrated Genomic Medical Research (CIGMR), University of Manchester, Manchester, United Kingdom.
Jenny Chang-ClaudeDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Petra SeiboldDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Catharine M L WestTranslational Radiobiology Group, Division of Cancer Sciences, Manchester Academic Health Science Centre, Christie Hospital, University of Manchester, Manchester, United Kingdom.
Tiziana RancatiProstate Cancer Program, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Fondazione IRCCS Istituto Nazionale dei Tumori · ITUniversity of Leicester · GBIcahn School of Medicine at Mount Sinai · USKU Leuven · BEMaastro Clinic · NLManchester Academic Health Science Centre · GBPolitecnico di Milano · ITGhent University Hospital · BEUniversity Medical Centre Mannheim · DEUniversity of Cambridge · GBUniversity of Milano-Bicocca · ITCentre for Biomedical Network Research on Rare Diseases · ESComplexo Hospitalario Universitario A Coruña · ESGerman Cancer Research Center · DEGhent University · BEHeidelberg University · DEHuman Technopole · ITInstituto de Investigación Sanitaria de Santiago · ESMRC Epidemiology Unit · GBUniversité de Montpellier · FR
Funding
Risk Prediction for Development of Adverse Effects FOllowing Radiotherapy for Prostate CancerK07CA187546 · NCI · UNIVERSITY OF ROCHESTER · PI KERNS, SARAH L. · 2015 to 2019
$649kCancer Research UK 16565Department of Health DRF-2014-07-079Medical Research Council MC_UU_00002/5NCI NIH HHS K07 CA187546
Abstract
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autoencoderdeep learninglate toxicityprostate cancersnpsvalidation
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