Evidence map›Paper›PMID 33178397›Full record

ArticleWorld journal of stem cells2020

Fabrice F Darche, Rasmus Rivinius, Ann-Kathrin Rahm, Eva Köllensperger, Uwe Leimer, Günter Germann, Miriam Reiss, Michael Koenen, Hugo A Katus, Dierk Thomas and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of stem cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Fabrice F DarcheDepartment of Cardiology, Medical University Hospital Heidelberg, Heidelberg D-69120, Germany.
Rasmus RiviniusDepartment of Cardiology, Medical University Hospital Heidelberg, Heidelberg D-69120, Germany.
Ann-Kathrin RahmDepartment of Cardiology, Medical University Hospital Heidelberg, Heidelberg D-69120, Germany.
Eva KöllenspergerDepartment of Plastic Surgery, ETHIANUM Klinik Heidelberg, Heidelberg D-69115, Germany.
Uwe LeimerDepartment of Plastic Surgery, ETHIANUM Klinik Heidelberg, Heidelberg D-69115, Germany.
Günter GermannDepartment of Plastic Surgery, ETHIANUM Klinik Heidelberg, Heidelberg D-69115, Germany.
Miriam ReissDepartment of Cardiology, Medical University Hospital Heidelberg, Heidelberg D-69120, Germany.
Michael KoenenDepartment of Cardiology, Medical University Hospital Heidelberg, Heidelberg D-69120, Germany.
Hugo A KatusDepartment of Cardiology, Medical University Hospital Heidelberg, Heidelberg D-69120, Germany.
Dierk ThomasDepartment of Cardiology, Medical University Hospital Heidelberg, Heidelberg D-69120, Germany.
Patrick A SchweizerDepartment of Cardiology, Medical University Hospital Heidelberg, Heidelberg D-69120, Germany.
Heidelberg University · DEUniversity Hospital Heidelberg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMesenchymal stem cells (MSC) modified by gene transfer to express cardiac pacemaker channels such as HCN2 or HCN4 were shown to elicit pacemaker function after intracardiac transplantation in experimental animal models. Human MSC derived from adipose tissue (haMSC) differentiate into cells with pacemaker properties

aimTo investigate whether haMSC elicit biological pacemaker function

methodshaMSC under native conditions (nhaMSC) or after pre-conditioning by medium differentiation (dhaMSC) (

results

conclusiondhaMSC transplanted into pig left ventricles sustainably induced rate-responsive ventricular pacemaker activity after

Indexed as

Animal modelBiological cardiac pacemakerCell transplantationDifferentiationMesenchymal stem cellsStem cell therapy

Identifiers

PMID33178397
PMCPMC7596441
OpenAlexW3097188544

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.