Evidence map›Paper›PMID 33178352›Full record

ArticleExperimental and therapeutic medicine2020

Expression profiles of the Wnt/β-catenin signaling-related extracellular antagonists during proliferation and differentiation in human osteoblast-like cells.

Alma Y Parra-Torres, Juana Enríquez, Rogelio F Jiménez-Ortega, Nelly Patiño, Manuel De Jesús Castillejos-López, Luz M Torres-Espíndola, Eric G Ramírez-Salazar, Rafael Velázquez-Cruz

Open access · diamondAbstract read
In one paragraph

Article in Experimental and therapeutic medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. The role of wnt signaling in diabetes-induced osteoporosis.Diabetology & metabolic syndrome · 2023
    Review
  2. International journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Alma Y Parra-TorresGenomics of Bone Metabolism Laboratory, National Institute of Genomic Medicine (INMEGEN), Mexico City 14610, Mexico.
Juana EnríquezDepartment of Reproduction Biology Carlos Gual Castro, National Institute of Medical Sciences and Nutrition Salvador Zubirán (INCMNSZ), Mexico City 14080, Mexico.
Rogelio F Jiménez-OrtegaGenomics of Bone Metabolism Laboratory, National Institute of Genomic Medicine (INMEGEN), Mexico City 14610, Mexico.
Nelly PatiñoSubdirection of Clinical Applications Development, National Institute of Genomic Medicine (INMEGEN), Mexico City 14610, Mexico.
Manuel De Jesús Castillejos-LópezEpidemiological Surveillance Unit, National Institute of Respiratory Diseases (INER) 'Ismael Cosío Villegas', Mexico City 14080, Mexico.
Luz M Torres-EspíndolaPharmacology Laboratory, National Institute of Pediatrics (INP), Mexico City 04530, Mexico.
Eric G Ramírez-SalazarNational Council for Science and Technology (CONACYT)-National Institute of Genomic Medicine (INMEGEN), Mexico City 14610, Mexico.
Rafael Velázquez-CruzGenomics of Bone Metabolism Laboratory, National Institute of Genomic Medicine (INMEGEN), Mexico City 14610, Mexico.
National Institute of Genomic Medicine · MXConsejo Nacional de Humanidades, Ciencias y Tecnologías · MXInstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bone formation is a dynamic process directed by osteoblast activity. The transition from the proliferation to differentiation stage during osteoblast maturation involves the downregulation of the Wnt/β-catenin signaling pathway, and extracellular antagonists are important for the regulation of Wnt signaling. However, the expression levels of Wnt antagonists in these stages of human osteoblast maturation have not been fully elucidated. Therefore, the aim of the present study was to investigate the expression levels of extracellular Wnt antagonists during proliferation and differentiation in osteoblast-like cell lines. The results demonstrated an overlap between the differential expression of secreted Frizzled-related protein (

Indexed as

extracellular Wnt antagonistsosteoblast differentiationosteoblast proliferationosteoblastsWnt/β-catenin pathway

Identifiers

PMID33178352
PMCPMC7654218
OpenAlexW3094087319

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.