Evidence map›Paper›PMID 33178222›Full record

ArticleFrontiers in immunology2020

Towards Precision Vaccines: Lessons From the Second International Precision Vaccines Conference.

Dheeraj Soni, Simon D Van Haren, Olubukola T Idoko, Jay T Evans, Joann Diray-Arce, David J Dowling, Ofer Levy

Open access · goldAbstract readConference Proceedings
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
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  5. Review
  6. Circular RNA: A promising new star of vaccine.Journal of translational internal medicine · 2023
    Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Precision Vaccine Adjuvants for Older Adults: A Scoping Review.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022
    Article
  16. Article
  17. Article
  18. Article
  19. Editorial: Immunity in Compromised Newborns.Frontiers in immunology · 2021
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Dheeraj SoniPrecision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, United States.
Simon D Van HarenPrecision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, United States.
Olubukola T IdokoPrecision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, United States.
Jay T EvansCenter for Translational Medicine, University of Montana, Missoula, MT, United States.
Joann Diray-ArcePrecision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, United States.
David J DowlingPrecision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, United States.
Ofer LevyPrecision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, United States.
Boston Children's Hospital · USBroad Institute · USHarvard University · USUniversity of Montana · US

Funding

Transcriptomics to define biomarkers of neonatal vaccine immunogenicityU19AI118608 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI LEVY, OFER · 2017 to 2021
$24.7M
Small-molecule adjuvants to enhance the efficacy of flu vaccines in newborns and the elderly75N93019C00044 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI LEVY, OFER · 2019 to 2023
$11.0M
Dissecting the mechanism of age-specific adjuvant synergy in vitro and in vivoU01AI124284 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI LEVY, OFER · 2016 to 2020
$2.9M
Leveraging immunostimulatory pathways that enhance BCG vaccination for the rational design of synthetic neonatal vaccine formulationsR21AI137932 · NIAID · NORTHWESTERN UNIVERSITY · PI DOWLING, DAVID JAMES, SCOTT, EVAN ALEXANDER · 2019 to 2020
$468k
Chief Scientist OfficeNIAID NIH HHS 75N93019C00044NIAID NIH HHS HHSN272201400052CNIAID NIH HHS HHSN272201800047CNIAID NIH HHS R21 AI137932NIAID NIH HHS U01 AI124284NIAID NIH HHS U19 AI118608
6 · The paper itself

Abstract

Other than clean drinking water, vaccines have been the most effective public health intervention in human history, yet their full potential is still untapped. To date, vaccine development has been largely limited to empirical approaches focused on infectious diseases and has targeted entire populations, potentially disregarding distinct immunity in vulnerable populations such as infants, elders, and the immunocompromised. Over the past few decades innovations in genetic engineering, adjuvant discovery, formulation science, and systems biology have fueled rapid advances in vaccine research poised to consider demographic factors (

Indexed as

Precision MedicineVaccinesAnimalsHumansVaccinesadjuvantsformulationsInternational Precision Vaccines Conferencenon-infectious diseasesprecision vaccinessystems biologyvaccinologistsvulnerable populations

Identifiers

PMID33178222
PMCPMC7593811
OpenAlexW3093373362

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.