Evidence map›Paper›PMID 33178188›Full record

ArticleFrontiers in immunology2020

Umbilical Cord Blood and iPSC-Derived Natural Killer Cells Demonstrate Key Differences in Cytotoxic Activity and KIR Profiles.

Benjamin H Goldenson, Huang Zhu, YunZu Michele Wang, Naveen Heragu, Davide Bernareggi, Alessa Ruiz-Cisneros, Andres Bahena, Eivind Heggernes Ask, Hanna Julie Hoel, Karl-Johan Malmberg and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 63 citations in OpenAlex.

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  14. Adoptive Cell Therapy from the Dish: Potentiating Induced Pluripotent Stem Cells.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2025
    Review
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  17. GMP Manufacturing of Allogenic iPSC-NK Cells for Immunotherapy.Advances in experimental medicine and biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 3 countries.

Benjamin H GoldensonDivision of Regenerative Medicine, Department of Medicine, University of California, San Diego, San Diego, CA, United States.
Huang ZhuDivision of Regenerative Medicine, Department of Medicine, University of California, San Diego, San Diego, CA, United States.
YunZu Michele WangDivision of Regenerative Medicine, Department of Medicine, University of California, San Diego, San Diego, CA, United States.
Naveen HeraguDivision of Regenerative Medicine, Department of Medicine, University of California, San Diego, San Diego, CA, United States.
Davide BernareggiDivision of Regenerative Medicine, Department of Medicine, University of California, San Diego, San Diego, CA, United States.
Alessa Ruiz-CisnerosDivision of Regenerative Medicine, Department of Medicine, University of California, San Diego, San Diego, CA, United States.
Andres BahenaDivision of Regenerative Medicine, Department of Medicine, University of California, San Diego, San Diego, CA, United States.
Eivind Heggernes AskDepartment of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.
Hanna Julie HoelDepartment of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.
Karl-Johan MalmbergDepartment of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.
Dan S KaufmanDivision of Regenerative Medicine, Department of Medicine, University of California, San Diego, San Diego, CA, United States.
University of California, San Diego · USOslo University Hospital · NO

Funding

A Rational Systematic Approach to Find Combinations of Pharmacologic and Immune Therapies that Target Identifiable Oncogenic StatesU01CA217885 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI COHEN, EZRA, KAUFMAN, DAN S. · 2017 to 2021
$5.1M
Expression of recombinant Fc receptors by engineered NK cells to enhance cancer cell killingR01CA203348 · NCI · UNIVERSITY OF MINNESOTA · PI WALCHECK, BRUCE K, WU, JIANMING · 2016 to 2025
$4.4M
NCI NIH HHS R01 CA203348NCI NIH HHS U01 CA217885
6 · The paper itself

Abstract

Natural killer (NK) cells derived or isolated from different sources have been gaining in importance for cancer therapies. In this study, we evaluate and compare key characteristics between NK cells derived or isolated from umbilical cord blood, umbilical cord blood hematopoietic stem/progenitor cells, peripheral blood, and induced pluripotent stem cells (iPSCs). Specifically, we find CD56

Indexed as

Cell DifferentiationCell Line, TumorCell SurvivalFetal BloodGenotypeHematopoietic Stem CellsHistocompatibility Antigens Class IHLA AntigensHumansInduced Pluripotent Stem CellsKiller Cells, NaturalNeuroblastomaReceptors, KIRTransfectionHistocompatibility Antigens Class IHLA AntigensReceptors, KIRcancerKIRsnatural killer cellsstem cellsumbilical cord blood

Identifiers

PMID33178188
PMCPMC7593774
OpenAlexW3092848755

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.