Evidence map›Paper›PMID 33178186›Full record

ArticleFrontiers in immunology2020

The Novel Omega-6 Fatty Acid Docosapentaenoic Acid Positively Modulates Brain Innate Immune Response for Resolving Neuroinflammation at Early and Late Stages of Humanized APOE-Based Alzheimer's Disease Models.

Qiu-Lan Ma, Cansheng Zhu, Marco Morselli, Trent Su, Matteo Pelligrini, Zhengqi Lu, Mychica Jones, Paul Denver, Daniel Castro, Xuelin Gu and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 48 citations in OpenAlex.

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  18. Malaysian brown macroalgaIranian journal of basic medical sciences · 2023
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 2 countries.

Qiu-Lan MaDepartment of Neurology, University of California, Los Angeles, Los Angeles, CA, United States.
Cansheng ZhuDepartment of Neurology, University of California, Los Angeles, Los Angeles, CA, United States.
Marco MorselliDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA, United States.
Trent SuInstitute for Quantitative and Computational Biology, University of California, Los Angeles, Los Angeles, CA, United States.
Matteo PelligriniDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA, United States.
Zhengqi LuDepartment of Neurology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Mychica JonesDepartment of Neurology, University of California, Los Angeles, Los Angeles, CA, United States.
Paul DenverDepartment of Neurology, University of California, Los Angeles, Los Angeles, CA, United States.
Daniel CastroDepartment of Neurology, University of California, Los Angeles, Los Angeles, CA, United States.
Xuelin GuDepartment of Neurology, University of California, Los Angeles, Los Angeles, CA, United States.
Frances RelampagosDepartment of Neurology, University of California, Los Angeles, Los Angeles, CA, United States.
Kaitlin CaoiliDepartment of Neurology, University of California, Los Angeles, Los Angeles, CA, United States.
Bruce TeterDepartment of Neurology, University of California, Los Angeles, Los Angeles, CA, United States.
Sally A FrautschyDepartment of Neurology, University of California, Los Angeles, Los Angeles, CA, United States.
Gregory M ColeDepartment of Neurology, University of California, Los Angeles, Los Angeles, CA, United States.
University of California, Los Angeles · USQB3 · USSun Yat-sen University · CN

Funding

Modulation of TGF-beta signaling by omega-6 polyunsaturated fatty acids for treating Alzheimer's diseaseR21AG069100 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MA, QIULAN · 2020 to 2021
$429k
Modulation of tau pathogenesis by high dietary fat, gender and ApoE isoformR21AG050269 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FRAUTSCHY, SALLY ANN · 2016 to 2017
$347k
Mechanisms for NSAID Alzheimer PreventionI01BX000542 · VA · VA GREATER LOS ANGELES HEALTHCARE SYSTEM · PI COLE, GREGORY M · 2009 to 2013
–
BLRD VA I01 BX000542NIA NIH HHS R21 AG050269NIA NIH HHS R21 AG069100
6 · The paper itself

Abstract

Neuroinflammation plays a crucial role in the development and progression of Alzheimer's disease (AD), in which activated microglia are found to be associated with neurodegeneration. However, there is limited evidence showing how neuroinflammation and activated microglia are directly linked to neurodegeneration

Indexed as

Immunity, InnateAlzheimer DiseaseAnimalsApolipoproteins EBrainCytokinesDisease Models, AnimalDisease SusceptibilityFatty Acids, Omega-6Fatty Acids, UnsaturatedImmunohistochemistryInflammation MediatorsMiceMice, TransgenicMicrogliaNeurodegenerative DiseasesApolipoproteins ECytokinesdocosapentaenoic acidFatty Acids, Omega-6Fatty Acids, UnsaturatedInflammation MediatorsAlzheimer's diseaseAPOEdocosapentaenoic acidEFADfatty acidlinoleic acidneuroinflammation

Identifiers

PMID33178186
PMCPMC7596305
OpenAlexW3093096604

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.