Evidence map›Paper›PMID 33178175›Full record

ArticleFrontiers in microbiology2020

Molecular Pap Smear: Validation of HPV Genotype and Host Methylation Profiles of

Jane Shen-Gunther, Qingqing Xia, Winfred Stacey, Heisy B Asusta

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. HPV Infection and Oral Microbiota: Interactions and Future Implications.International journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Jane Shen-GuntherGynecologic Oncology & Clinical Investigation, Department of Clinical Investigation, Brooke Army Medical Center, Fort Sam Houston, TX, United States.
Qingqing XiaDepartment of Clinical Investigation, Brooke Army Medical Center, Fort Sam Houston, TX, United States.
Winfred StaceyDepartment of Clinical Investigation, Brooke Army Medical Center, Fort Sam Houston, TX, United States.
Heisy B AsustaDepartment of Obstetrics and Gynecology, Brooke Army Medical Center, Fort Sam Houston, TX, United States.
Joint Base San Antonio · USSan Antonio Military Medical Center · USThe University of Texas Health Science Center at San Antonio · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Primary high-risk Human Papillomavirus (hrHPV) screening has recently become an accepted standalone or co-test with conventional cytology. Unfortunately, hrHPV singularly lacks specificity for cytopathological grade. However, mechanisms and markers of evolving virus-host interactions at the epigenome level may be harnessed as a better predictor of carcinogenesis. This study aimed to validate and expand the clinical performance of a multiparametric biomarker panel, referred to as the "Molecular Pap smear" based, on HPV genotype and

Indexed as

carcinogenesisDNA methylationepigenetic modificationevolutionhost-pathogen interactionshuman papillomavirus infectionpap smearpyrosequencing

Identifiers

PMID33178175
PMCPMC7593258
OpenAlexW3093056205

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.