ArticleFrontiers in neurology2020
Do We Belittle Essential Tremor by Calling It a Syndrome Rather Than a Disease? Yes.
Article in Frontiers in neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Tremor pathophysiology.Clinical parkinsonism & related disorders · 2026Review
- 2023 International Rome consensus for the nomenclature of Sjögren disease.Nature reviews. Rheumatology · 2025Article
- Assessing ChatGPT Ability to Answer Frequently Asked Questions About Essential Tremor.Tremor and other hyperkinetic movements (New York, N.Y.) · 2024Article
- [Essential tremor: are we just splitting hairs? Non-motor symptoms and essential tremor-plus].Revista de neurologia · 2023Review
- Diagnosis Versus Classification of Essential Tremor: A Research Perspective.Journal of movement disorders · 2023Article
- Reclassification of patients with tremor syndrome and comparisons of essential tremor and essential tremor-plus patients.Journal of neurology · 2022Observational
- Essential Tremor: Five New Things.Neurology. Clinical practice · 2022Article
- Brain Donation Decisions as Disease Specific Behaviors: An Elucidation of the Donation Process in the Context of Essential Tremor.Tremor and other hyperkinetic movements (New York, N.Y.) · 2022Article
- What's in a Name? Nomenclature of essential tremor: Syndrome or family of diseases?International review of neurobiology · 2022Article
- Features of "ET plus" correlate with age and tremor duration: "ET plus" may be a disease stage rather than a subtype of essential tremor.Parkinsonism & related disorders · 2021Article
- Phenotypic Features of Isolated Essential Tremor, Essential Tremor Plus, and Essential Tremor-Parkinson's Disease in a Movement Disorders Clinic.Tremor and other hyperkinetic movements (New York, N.Y.) · 2021Article
- Tremor Syndromes: An Updated Review.Frontiers in neurology · 2021Review
- Essential tremor: Is the word "essential" really essential?Parkinsonism & related disorders · 2020Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Essential tremor (ET) is among the most prevalent neurological diseases. Appreciation in recent years of a richer tremor phenomenology, additional motor and non-motor features, variability in the natural course of tremor, associations with a host of other neurological conditions, and etiological and pathophysiological heterogeneity have resulted in general awareness of the clinical richness of ET. Along with this evolving view of ET have surfaced several conundrums regarding nomenclature. One of these is whether ET should be labeled a "syndrome" or "disease." Here, we revisit the classical definitions of "syndrome" and "disease" and discuss ET in this context. Considering the characteristics of "disease" and "syndrome" and evaluating the characteristics of ET, it seems to fit more into the "disease" construct. There are several reasons: There is considerable knowledge of the underlying etiologies and pathophysiology of ET, in numerous studies ET has been linked with other neurological conditions, the condition is progressive and deteriorative, and therapeutic approaches are grounded in an understanding of disease mechanisms and its associated neuroanatomy. Moreover, the etiological-pathological-clinical heterogeneity suggests that ET should be regarded as a "family of diseases" more appropriately termed "the essential tremors." This nomenclatural issue is not a mere matter of words; public health implications are numerous. A condition with the label "syndrome" may not be recognized as a serious problem, may be plagued by diminished public awareness, and may not garner funds for research that a condition with the label "disease" or "diseases" would. ET should be regarded as a family of diseases.
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