ArticleFrontiers in physiology2020
Epicardial Adipose Tissue and IL-13 Response to Myocardial Injury Drives Left Ventricular Remodeling After ST Elevation Myocardial Infarction.
Article in Frontiers in physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Association between Epicardial Adipose Tissue Volume and Changes in Left Ventricular Ejection Fraction in Patients with Acute Coronary Syndrome.Journal of atherosclerosis and thrombosis · 2026Article
- Correlation of ventricle epicardial fat volume and triglyceride-glucose index in patients with chronic heart failure.The international journal of cardiovascular imaging · 2024Article
- The Role of Epicardial Adipose Tissue in Acute Coronary Syndromes, Post-Infarct Remodeling and Cardiac Regeneration.International journal of molecular sciences · 2024Review
- Impact of Epicardial Adipose Tissue on Infarct Size and Left Ventricular Systolic Function in Patients with Anterior ST-Segment Elevation Myocardial Infarction.Diagnostics (Basel, Switzerland) · 2024Article
- IL-13 promotes functional recovery after myocardial infarction via direct signaling to macrophages.JCI insight · 2024Article
- Interleukin 4/13 signaling in cardiac regeneration and repair.American journal of physiology. Heart and circulatory physiology · 2022Review
- Importance of cardiac imaging assessment of epicardial adipose tissue after a first episode of myocardial infarction.Frontiers in cardiovascular medicine · 2022Article
- Article
- Epicardial Adipose Tissue and Cardiac Arrhythmias: Focus on Atrial Fibrillation.Frontiers in cardiovascular medicine · 2022Review
- Interrelationship and Sequencing of Interleukins4, 13, 31, and 33 - An Integrated Systematic Review: Dermatological and Multidisciplinary Perspectives.Journal of inflammation research · 2022Review
- In severe obesity, subcutaneous adipose tissue cell-derived cytokines are early markers of impaired glucose tolerance and are modulated by quercetin.International journal of obesity (2005) · 2021Article
- Epicardial adipose tissue and severe Coronavirus Disease 19.Cardiovascular diabetology · 2021Article
- Emerging role of interleukin-13 in cardiovascular diseases: A ray of hope.Journal of cellular and molecular medicine · 2021Review
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Authors and funding
15 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionLeft ventricular (LV) remodeling after ST-segment elevation myocardial infarction (STEMI) is explained only in part by the infarct size, and the inter-patient variability may be ascribed to different inflammatory response to myocardial injury. Epicardial adipose tissue (EAT) is a source of inflammatory mediators which directly modulates the myocardium. EAT increase is associated to several cardiovascular diseases; however, its response to myocardial injury is currently unknown. Among inflammatory mediators, IL-13 seems to play protective role in LV regeneration, but its variations after STEMI have not been described yet. Purpose: In the present study we analyzed the association between infarct-related changes of EAT and IL-13 in post-STEMI LV remodeling.
methodsWe enrolled 100 patients with STEMI undergoing primary angioplasty. At the enrolment (T0) and after 3 months (T1), we measured EAT thickness by echocardiography and circulating levels of IL-13 by ELISA.
resultsAt T1, the 60% of patients displayed increased EAT thickness (ΔEAT > 0). ΔEAT was directly associated to LV end-diastolic volume (
conclusionThe variability of STEMI-induced "inflammatory response" may be associated to the post-infarct LV remodeling. ΔEAT thickness and ΔIL-13 levels could be novel prognostic markers in STEMI patients.
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