Evidence map›Paper›PMID 33177984›Full record

ArticleFrontiers in neuroscience2020

Investigating the Relationship Between Neuronal Cell Death and Early DNA Methylation After Ischemic Injury.

Mayumi Asada, Hideki Hayashi, Kenjiro Murakami, Kento Kikuiri, Ryotaro Kaneko, Bo Yuan, Norio Takagi

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 31 citations in OpenAlex.

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  12. Epigenetic mechanisms and potential therapeutic targets in stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022
    Review
  13. The Role of DNA Methylation in Stroke Recovery.International journal of molecular sciences · 2022
    Review
  14. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Mayumi AsadaDepartment of Applied Biochemistry, Tokyo University of Pharmacy and Life Sciences, Hachioji, Japan.
Hideki HayashiDepartment of Applied Biochemistry, Tokyo University of Pharmacy and Life Sciences, Hachioji, Japan.
Kenjiro MurakamiDepartment of Applied Biochemistry, Tokyo University of Pharmacy and Life Sciences, Hachioji, Japan.
Kento KikuiriDepartment of Applied Biochemistry, Tokyo University of Pharmacy and Life Sciences, Hachioji, Japan.
Ryotaro KanekoDepartment of Applied Biochemistry, Tokyo University of Pharmacy and Life Sciences, Hachioji, Japan.
Bo YuanLaboratory of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, School of Pharmacy, Josai University, Sakado, Japan.
Norio TakagiDepartment of Applied Biochemistry, Tokyo University of Pharmacy and Life Sciences, Hachioji, Japan.
Tokyo University of Pharmacy and Life Sciences · JPJosai University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cerebral ischemia induces neuronal cell death and causes various kinds of brain dysfunction. Therefore, prevention of neuronal cell death is most essential for protection of the brain. On the other hand, it has been reported that epigenetics including DNA methylation plays a pivotal role in pathogenesis of some diseases such as cancer. Accumulating evidences indicate that aberrant DNA methylation is related to cell death. However, DNA methylation after cerebral ischemia has not been fully understood yet. The aim of this present study was to investigate the relationships between DNA methylation and neuronal cell death after cerebral ischemia. We examined DNA methylation under the ischemic condition by using transient middle cerebral artery occlusion and reperfusion (MCAO/R) model rats and

Indexed as

cerebral ischemiaDNA methylationDNMT3aneuronal cell deathNMDAprimary cultured cortical neurontransient MCAO

Identifiers

PMID33177984
PMCPMC7591788
OpenAlexW3097847407

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.