ArticleNature and science of sleep2020
Gut Microbiota Changes and Their Relationship with Inflammation in Patients with Acute and Chronic Insomnia.
Article in Nature and science of sleep, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05917379 (The Safety and Efficacy of Fecal Microbiota Transplantation in Patients With Chronic Insomnia Disorder), which is not on this map. Cited by 92 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Safety and Efficacy of Fecal Microbiota Transplantation in Patients With Chronic Insomnia Disorder
Who cites it
92 citing papers in PubMed, 5 syntheses or guidelines pooled it, 145 citations in OpenAlex.
- Sleep disorders increase the risk of dementia, Alzheimer's disease, and cognitive decline: a meta-analysis.GeroScience · 2025Pooled it
- Mapping the research landscape of traditional Chinese medicine in insomnia management: a bibliometric study (2005-2024).Frontiers in neurology · 2025Pooled it
- The Microbiota-Gut-Brain Axis in Metabolic Syndrome and Sleep Disorders: A Systematic Review.Nutrients · 2024Pooled it
- Changes in Gut Microbiota and Multiple Sclerosis: A Systematic Review.International journal of environmental research and public health · 2023Pooled it
- Gut microbiome changes due to sleep disruption in older and younger individuals: a case for sarcopenia?Sleep · 2022Pooled it
- The Effects of a Multidomain Lifestyle Intervention on Brain Function and Its Relation With Immunometabolic Markers and Intestinal Health in Older Adults at Risk of Cognitive Decline: Study Design and Baseline Characteristics of the HELI Randomized Controlled Trial.JMIR research protocols · 2025Trial
- Bifidobacterium longum 1714 improves sleep quality and aspects of well-being in healthy adults: a randomized, double-blind, placebo-controlled clinical trial.Scientific reports · 2024Trial
- Role and mechanism of gut microbiota and metabolites in schizophrenia complicated with sleep disorder.Gut microbes · 2026Review
- Causal links between gut microbiota, plasma metabolites, and insomnia: Insights from Mendelian randomization.Dialogues in clinical neuroscience · 2026Article
- Integrative multi-omics profiling of insomnia-related molecular features reveals microbiome, immune, and therapy-relevant heterogeneity in colorectal cancer.Microbiology spectrum · 2026Article
- Faecalibacterium prausnitzii-derived L-arginine ameliorates insomnia by inhibiting POMC-ACTH-cortisol axis.Cell reports. Medicine · 2026Article
- From Mechanisms to Practice: Gut Microbiome-Based Strategies for Supporting Recovery in Elite Athletes.Nutrients · 2026Review
- Total glucosides of Paeony alleviates chronic endometritis in rats through regulating gut microbiota composition and inhibiting TLR4/NF-κB/NLRP3 pathway.Orphanet journal of rare diseases · 2026Article
- Article
- From alpha diversity to zeitgebers: Functional implications and potential mechanisms linking the gut microbiome to sleep and circadian disruption (Part II).Neuroscience and biobehavioral reviews · 2026Review
- Associations of probiotics, prebiotics, synbiotics, and yogurt supplements with oxidative balance scores and all-cause and cardiovascular mortalities in neuropsychiatric disorders.American heart journal plus : cardiology research and practice · 2026Article
- From alpha diversity to zeitgebers: Bacterial gut microbiome associations with sleep and circadian disruption (Part I).Neuroscience and biobehavioral reviews · 2026Review
- Analysis of gut microbiota in Restless Legs Syndrome: searching for a metagenomic signature.Sleep · 2026Article
- The Gut Microbiome in Sleep Disorders: A Review of Recent Evidence.Actas espanolas de psiquiatria · 2026Review
- The Microbiota-Gut-Brain Axis in Insomnia: Mechanisms and Intervention Strategies.Life (Basel, Switzerland) · 2026Review
32 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe major purpose of this study was to detect the changes in gut microbiota composition and inflammatory cytokines production associated with acute and chronic insomnia. This study also evaluated the relationship between gut microbiota changes and increased inflammatory cytokines in insomnia patients. PATIENTS AND
methodsOutpatients with acute and chronic insomnia (aged 26-55 years; n=20 and 38, respectively) and age/gender-matched healthy controls (n=38) were recruited from a southern China region. Participants' gut microbiome, plasma cytokines, and self-reported sleep quality and psychopathological symptoms were measured.
resultsThe gut microbiomes of insomnia patients compared with healthy controls were characterized by lower microbial richness and diversity, depletion of anaerobes, and short-chain fatty acid (SCFA)-producing bacteria, and an expansion of potential pathobionts.
conclusionThese findings suggest that insomnia symptomology, gut microbiota, and inflammation may be interrelated in complex ways. Gut microbiota may serve as an important indicator for auxiliary diagnosis of insomnia and provide possible new therapeutic targets in the field of sleep disorders.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.