Evidence map›Paper›PMID 33177822›Full record

ArticleInternational journal of nanomedicine2020

Multi-Stimuli-Responsive DOX Released from Magnetosome for Tumor Synergistic Theranostics.

Ming-Fong Tsai, Yu-Lun Lo, Yuan-Chun Huang, Chun-Chieh Yu, Yi-Ting Wu, Chia-Hao Su, Li-Fang Wang

Open access · goldAbstract read
In one paragraph

Article in International journal of nanomedicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Modified gefitinib conjugated FeFrontiers in bioengineering and biotechnology · 2023
    Article
  6. Article
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  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Ming-Fong Tsai *Department of Medicinal & Applied Chemistry, College of Life Sciences, Kaohsiung Medical University, Kaohsiung 807, Taiwan.ORCID 0000-0002-4767-696X
Yu-Lun Lo *Department of Medicinal & Applied Chemistry, College of Life Sciences, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Yuan-Chun HuangDepartment of Medicinal & Applied Chemistry, College of Life Sciences, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Chun-Chieh YuInstitute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan.
Yi-Ting WuDepartment of Medicinal & Applied Chemistry, College of Life Sciences, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Chia-Hao SuInstitute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan.
Li-Fang WangDepartment of Medicinal & Applied Chemistry, College of Life Sciences, Kaohsiung Medical University, Kaohsiung 807, Taiwan.ORCID 0000-0003-1593-4482
Kaohsiung Medical University · TWKaohsiung Chang Gung Memorial Hospital · TWNational Yang Ming Chiao Tung University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo improve responses to tumor microenvironments for achieving a better therapeutic outcome in combination cancer therapy, poly(ε-caprolactone)-SS-poly(methacrylic acid) diblock copolymer (PCL-SS-PMAA) with a disulfide linkage between the hydrophobic and hydrophilic junctions was synthesized. MATERIALS AND

methodsRepeating units of PCL and PMAA in PCL-SS-PMAA were controlled and formulated into polymersomes (PSPps). Truncated octahedral Fe

resultsIONPs-PSPps NPs remained a superparamagnetic property with a saturation magnetization value of 85 emu⋅g

conclusionIONPs-PSPps@DOX NPs are a potential theranostic agent having multifaceted applications involving magnetic targeting, MRI diagnosis, hyperthermia and chemotherapy.

Indexed as

A549 CellsAnimalsAntibiotics, AntineoplasticApoptosisDoxorubicinDrug Delivery SystemsDrug LiberationHumansMagnetic Resonance ImagingMagnetosomesMaleMetal NanoparticlesMice, Inbred BALB CNeoplasms, ExperimentalPolyestersPolymethacrylic AcidsAntibiotics, AntineoplasticDoxorubicinpolycaprolactonePolyestersPolymethacrylic Acidshyperthermiamagnetic resonance imagingmagnetosomemulti-stimuli-responsive copolymertheranostics

Identifiers

PMID33177822
PMCPMC7652232
OpenAlexW3095821122

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.