Evidence map›Paper›PMID 33177716›Full record

ArticleNature2020

Chemico-genetic discovery of astrocytic control of inhibition in vivo.

Tetsuya Takano, John T Wallace, Katherine T Baldwin, Alicia M Purkey, Akiyoshi Uezu, Jamie L Courtland, Erik J Soderblom, Tomomi Shimogori, Patricia F Maness, Cagla Eroglu and 1 more

Open access · greenAbstract read
In one paragraph

Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 150 papers.

0numbers the graph read from it
0cells of the map it votes in
150citing papers in PubMed
13.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

150 citing papers in PubMed, 242 citations in OpenAlex.

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90 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Tetsuya TakanoThe Department of Cell Biology, Duke University Medical School, Durham, NC, USA. tetsuya.takano@keio.jp.
John T WallaceThe Department of Cell Biology, Duke University Medical School, Durham, NC, USA.
Katherine T BaldwinThe Department of Cell Biology, Duke University Medical School, Durham, NC, USA.ORCID http://orcid.org/0000-0002-4423-5712
Alicia M PurkeyThe Department of Cell Biology, Duke University Medical School, Durham, NC, USA.
Akiyoshi UezuThe Department of Cell Biology, Duke University Medical School, Durham, NC, USA.
Jamie L CourtlandDepartment of Neurobiology, Duke University Medical School, Durham, NC, USA.ORCID http://orcid.org/0000-0001-6846-3552
Erik J SoderblomThe Department of Cell Biology, Duke University Medical School, Durham, NC, USA.
Tomomi ShimogoriMolecular Mechanisms of Brain Development, Center for Brain Science (CBS), RIKEN, Saitama, Japan.
Patricia F ManessDepartment of Biochemistry, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Cagla ErogluThe Department of Cell Biology, Duke University Medical School, Durham, NC, USA. cagla.eroglu@duke.edu.ORCID http://orcid.org/0000-0002-7204-0218
Scott H SoderlingThe Department of Cell Biology, Duke University Medical School, Durham, NC, USA. scott.soderling@duke.edu.ORCID http://orcid.org/0000-0001-7808-197X
Duke University · USRIKEN Center for Brain Science · JPUniversity of North Carolina at Chapel Hill · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007171 · NIGMS · DUKE UNIVERSITY · PI KONTOS, CHRISTOPHER D · 1985 to 2021
$31.2M
Analysis of Inhibitory Synaptic Proteins Associated with Brain DisordersR01NS102456 · NINDS · DUKE UNIVERSITY · PI SODERLING, SCOTT H · 2017 to 2021
$2.6M
New Proteomic and Genome Engineering Approaches to Decipher Astrocyte Function at SynapsesR01DA047258 · NIDA · DUKE UNIVERSITY · PI EROGLU, CAGLA, SODERLING, SCOTT H · 2018 to 2020
$2.1M
Mechanisms of Developmental Spine Pruning Regulated by IgCAMs and SemaphorinsR01MH113280 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MANESS, PATRICIA F · 2017 to 2021
$1.9M
Control of Astrocyte Development and Astrocyte-Synapse InteractionsR01NS102237 · NINDS · DUKE UNIVERSITY · PI EROGLU, CAGLA · 2018 to 2022
$1.9M
Interneuron Synapses: In Vivo Chemicogenetic Proteomics to Discover Developmental Brain Disorder EtiologiesF30MH117851 · NIMH · DUKE UNIVERSITY · PI COURTLAND, JAMIE LYNN · 2019 to 2021
$126k
NIDA NIH HHS R01 DA047258NIGMS NIH HHS T32 GM007171NIMH NIH HHS F30 MH117851NIMH NIH HHS R01 MH113280NINDS NIH HHS R01 NS102237NINDS NIH HHS R01 NS102456
6 · The paper itself

Abstract

Perisynaptic astrocytic processes are an integral part of central nervous system synapses

Indexed as

ProteomicsAnimalsAstrocytesCell Adhesion Molecules, NeuronalCell ShapeFemaleGABAergic Neuronsgamma-Aminobutyric AcidGenetic Complementation TestHEK293 CellsHumansMaleMiceNeural InhibitionNeuronsProteomeCell Adhesion Molecules, Neuronalgamma-Aminobutyric AcidProteome

Identifiers

PMID33177716
PMCPMC8011649
OpenAlexW3098524589

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.