Trial reportNature2020
A reference map of potential determinants for the human serum metabolome.
Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
In one paragraph
Trial report in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06573827 (The Urinary Microbiome and Its Relationship to the Urinary and Serum Metabolome in Healthy Peri- and Postmenopausal Women), which is not on this map. Cited by 282 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
282citing papers in PubMed, 1 pooled it
19.1field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Urinary Microbiome and Its Relationship to the Urinary and Serum Metabolome in Healthy Peri- and Postmenopausal Women
Who cites it
282 citing papers in PubMed, 1 synthesis or guideline pooled it, 430 citations in OpenAlex.
- Utilizing metabolomics to identify potential biomarkers and perturbed metabolic pathways in osteoarthritis: A systematic review.Seminars in arthritis and rheumatism · 2023Pooled it
- Blood Metabolomic Signatures of 1-Hour Glucose Predict Cardiometabolic Risk.Circulation research · 2026Trial
- Workplace food purchases, dietary intake, and gut microbial metabolites in a secondary analysis of the ChooseWell 365 study.The American journal of clinical nutrition · 2024Trial
- Impact of dietary interventions on pre-diabetic oral and gut microbiome, metabolites and cytokines.Nature communications · 2023Trial
- Trial
- Dietary Strawberries Improve Serum Metabolites of Cardiometabolic Risks in Adults with Features of the Metabolic Syndrome in a Randomized Controlled Crossover Trial.International journal of molecular sciences · 2023Trial
- Sex differences in the gut microbiome and related metabolites: role in cardiometabolic disease.Gut microbes · 2026Review
- Serum metabolic signatures of nutritional status in early childhood: results from the Brazilian National Survey on Child Nutrition (ENANI-2019).European journal of nutrition · 2026Article
- The Role of the Gut Microbiome in the Relationship Between the Mediterranean Diet and Cardiovascular Disease Risk.Current atherosclerosis reports · 2026Review
- Gut microbiota-derived imidazole propionate promotes primary sclerosing cholangitis via p38 signalling.Nature metabolism · 2026Article
- Metabolic Phenotyping Identifies Responders to Sustainable Healthy Diets: Analysis from the MyPlanetDiet Randomized Controlled Trial.Current developments in nutrition · 2026Article
- Plasma metabolomic signatures of migraine in 479,760 adults.iScience · 2026Article
- Type 2 diabetes prevention across the life course.Nature medicine · 2026Review
- Determinants of the plasma metabolome: cross-sectional and longitudinal associations over six years in the NESDA cohort.EBioMedicine · 2026Article
- Engineering microbial consortia for distributed signal processing.Nature communications · 2026Article
- Article
- The blood metabolome of brain health in midlife and influences of genes, microbiome and exposome.Nature aging · 2026Article
- Microbiome histidine competition mediates dietary control of systemic imidazole propionate.bioRxiv : the preprint server for biology · 2026Article
- Long-term metabolically unhealthy aging, its underlying molecular underpinnings, and association with cognitive impairment: a 12.4-year longitudinal cohort study.BMC medicine · 2026Article
- Aspiration to architecture: multi-omics, AI, digital twins, and blockchain for P4 medicine.Journal of translational medicine · 2026Article
222 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
19 authors at 20 institutions in 15 countries.
Noam Bar *Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel.
Tal Korem *Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel.ORCID http://orcid.org/0000-0002-0609-0858
Omer WeissbrodDepartment of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel.
David ZeeviDepartment of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel.ORCID http://orcid.org/0000-0002-6492-6078
Daphna RothschildDepartment of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel.
Sigal LeviatanDepartment of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel.
Noa KosowerDepartment of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel.
Maya Lotan-PompanDepartment of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel.
Adina WeinbergerDepartment of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel.
Caroline I Le RoyDepartment for Twin Research & Genetic Epidemiology, King's College London, London, UK.ORCID http://orcid.org/0000-0002-0341-751X
Cristina MenniDepartment for Twin Research & Genetic Epidemiology, King's College London, London, UK.
Alessia ViscontiDepartment for Twin Research & Genetic Epidemiology, King's College London, London, UK.ORCID http://orcid.org/0000-0003-4144-2019
Mario FalchiDepartment for Twin Research & Genetic Epidemiology, King's College London, London, UK.
Tim D SpectorDepartment for Twin Research & Genetic Epidemiology, King's College London, London, UK.ORCID http://orcid.org/0000-0002-9795-0365
IMI DIRECT consortium
Jerzy AdamskiResearch Unit Molecular Endocrinology and Metabolism, Genome Analysis Center, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.ORCID http://orcid.org/0000-0001-9259-0199
Paul W FranksLund University Diabetes Center, Department of Clinical Sciences, Lund University, Malmö, Sweden.ORCID http://orcid.org/0000-0002-0520-7604
Oluf PedersenThe Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-3321-3972
Eran SegalDepartment of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel. eran.segal@weizmann.ac.il.ORCID http://orcid.org/0000-0002-6859-1164
University of Copenhagen · DKUniversity of Dundee · GBLund University · SEUniversity of Oxford · GBWeizmann Institute of Science · ILAmsterdam Public Health · NLBoehringer Ingelheim (Germany) · DEHelmholtz Zentrum München · DEUniversity of Exeter · GBKing's College London · GBSanofi (Germany) · DEScience for Life Laboratory · SEUniversity of Eastern Finland · FICentre for Human Genetics · GBInserm · FRLeiden University Medical Center · NLSaarland University · DECentre National de la Recherche Scientifique · FREli Lilly (United States) · USNeuroscience Institute · IT
Funding
European Research CouncilMedical Research Council MR/M004422/1
Abstract
The serum metabolome contains a plethora of biomarkers and causative agents of various diseases, some of which are endogenously produced and some that have been taken up from the environment
Indexed as
DietAdultBreadCohort StudiesFemaleGastrointestinal MicrobiomeHealthy VolunteersHumansLife StyleMachine LearningMaleMetabolomeMetabolomicsMiddle AgedNon-alcoholic Fatty Liver DiseaseOxygenasesOxygenasesPHYHD1 protein, human
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
NCT06573827ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.