ArticleNature2020
Progressive Cactus is a multiple-genome aligner for the thousand-genome era.
Abstract readComparative Study
In one paragraph
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 376 papers.
0numbers the graph read from it
0cells of the map it votes in
376citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
376 citing papers in PubMed.
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- Regulatory activity and evolutionary co-option of cis-regulatory elements underlying bear hibernation.Molecular biology and evolution · 2026Article
- A curated genome-scale nucleotide diversity panel of non-human primates.Genome biology · 2026Article
- Developmental contexts of gene-regulatory evolution following whole genome duplication in salmonids.Nature ecology & evolution · 2026Article
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- Comparative analysis of conserved non-coding elements identifies gene regulatory networks rewired during the water-to-land transition in vertebrates.Biologia futura · 2026Article
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- The Rise of Plant Pan-Genomes: From Genome Variation to Predictive Breeding.Advanced genetics (Hoboken, N.J.) · 2026Article
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- Disruption of mitonuclear coadaptation and compensatory evolution after an extreme dietary shift in carnivorous butterflies.Molecular biology and evolution · 2026Article
- Topological mixing and irreversibility in animal chromosome evolution.Science advances · 2026Article
- A complete genome for the common marmoset.Cell · 2026Article
- Extensive binding of poorly characterized human transcription factors to genomic dark matter.Nature communications · 2026Article
- Estimating the evolutionary fitness of specific synonymous codon changes.Molecular biology and evolution · 2026Article
- Lineage-specific change in craniofacial gene regulatory networks of syngnathid fishes revealed by integrating multiomics across fishes.bioRxiv : the preprint server for biology · 2026Article
316 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
21 authors.
Joel ArmstrongUC Santa Cruz Genomics Institute, UC Santa Cruz, Santa Cruz, CA, USA.ORCID http://orcid.org/0000-0003-2077-4671
Glenn HickeyUC Santa Cruz Genomics Institute, UC Santa Cruz, Santa Cruz, CA, USA.
Mark DiekhansUC Santa Cruz Genomics Institute, UC Santa Cruz, Santa Cruz, CA, USA.ORCID http://orcid.org/0000-0002-0430-0989
Ian T FiddesUC Santa Cruz Genomics Institute, UC Santa Cruz, Santa Cruz, CA, USA.
Adam M NovakUC Santa Cruz Genomics Institute, UC Santa Cruz, Santa Cruz, CA, USA.ORCID http://orcid.org/0000-0001-5828-047X
Alden DeranUC Santa Cruz Genomics Institute, UC Santa Cruz, Santa Cruz, CA, USA.
Qi FangBGI-Shenzhen, Beishan Industrial Zone, Shenzhen, China.ORCID http://orcid.org/0000-0002-9181-8689
Duo XieBGI-Shenzhen, Beishan Industrial Zone, Shenzhen, China.ORCID http://orcid.org/0000-0001-7010-3601
Shaohong FengBGI-Shenzhen, Beishan Industrial Zone, Shenzhen, China.ORCID http://orcid.org/0000-0002-2462-7348
Josefin StillerSection for Ecology and Evolution, Department of Biology, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-6009-9581
Diane GenereuxBroad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.
Jeremy JohnsonBroad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.
Voichita Dana MarinescuScience for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.
Jessica AlföldiBroad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.
Robert S HarrisDepartment of Biology, The Pennsylvania State University, University Park, PA, USA.
Kerstin Lindblad-TohBroad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.
David HausslerUC Santa Cruz Genomics Institute, UC Santa Cruz, Santa Cruz, CA, USA.ORCID http://orcid.org/0000-0003-1533-4575
Elinor KarlssonBroad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-4343-3776
Erich D JarvisHoward Hughes Medical Institute, Chevy Chase, MD, USA.
Guojie ZhangSection for Ecology and Evolution, Department of Biology, University of Copenhagen, Copenhagen, Denmark. guojie.zhang@bio.ku.dk.ORCID http://orcid.org/0000-0001-6860-1521
Benedict PatenUC Santa Cruz Genomics Institute, UC Santa Cruz, Santa Cruz, CA, USA. bpaten@ucsc.edu.ORCID http://orcid.org/0000-0001-8863-3539
Funding
The WashU-UCSC-EBI Human Genome Reference Center."U41HG010972 · NHGRI · WASHINGTON UNIVERSITY · PI Ira M Hall, Heng Li · 2019 to 2026
$24.9MGENCODE Resource ProjectU41HG007234 · NHGRI · SANGER INSTITUTE · PI FLICEK, PAUL · 2013 to 2020
$20.3MELSI Administrative Supplement - Center for Human Reference Genome DiversityU01HG010971 · NHGRI · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI EICHLER, EVAN, JARVIS, ERICH D · 2019 to 2023
$18.4MGENCODE: comprehensive reference genome annotation for human and mouseU24HG007234 · NHGRI · EUROPEAN MOLECULAR BIOLOGY LABORATORY · PI Fergal James Martin · 2021 to 2026
$16.1MTraining SubprojectU54HG007990 · NHGRI · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI HAUSSLER, DAVID H, PATTERSON, DAVID · 2014 to 2018
$14.8MThe construction and utility of reference pan-genome graphsU01HG010961 · NHGRI · DANA-FARBER CANCER INST · PI LI, HENG, PATEN, BENEDICT · 2020 to 2023
$3.2MDockstore - A Platform for Sharing Tools & Workflows on the Cloud CommonsR01HG009737 · NHGRI · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI PATEN, BENEDICT, PHILIPPAKIS, ANTHONY · 2017 to 2020
$3.0MThe 200 mammals project: sequencing genomes by a novel cost-effective method, yielding a high resolution annotation of the human genome.R01HG008742 · NHGRI · BROAD INSTITUTE, INC. · PI BIRREN, BRUCE W., KARLSSON, ELINOR · 2016 to 2020
$2.8MEnabling Comparative PangenomicsR01HG010485 · NHGRI · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI HAUSSLER, DAVID H, MARTIN, FERGAL JAMES · 2020 to 2023
$2.6MUnbiased analysis of genomic correlates of gene expression in health and diseaseU01HL137183 · NHLBI · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI HAUSSLER, DAVID H · 2017 to 2019
$1.8MUC Santa Cruz Training Program In Genomic SciencesT32HG008345 · NHGRI · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI BROOKS, ANGELA NORIE, GREEN, RICHARD EDWARD · 2015 to 2020
$1.4MNHGRI NIH HHS R01 HG008742NHGRI NIH HHS R01 HG009737NHGRI NIH HHS R01 HG010485NHGRI NIH HHS T32 HG008345NHGRI NIH HHS U01 HG010961NHGRI NIH HHS U01 HG010971NHGRI NIH HHS U24 HG007234NHGRI NIH HHS U41 HG007234NHGRI NIH HHS U41 HG010972NHGRI NIH HHS U54 HG007990NHLBI NIH HHS U01 HL137183NIH HHS 5T32HG008345-04
Abstract
New genome assemblies have been arriving at a rapidly increasing pace, thanks to decreases in sequencing costs and improvements in third-generation sequencing technologies
Indexed as
SoftwareAmnionAnimalsComputer SimulationGenomeGenomicsHaplotypesHumansQuality ControlSequence AlignmentVertebrates
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.