ReviewNature reviews. Neuroscience2021
Inhibitory stabilization and cortical computation.
Review in Nature reviews. Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
78 citing papers in PubMed.
- Dynamic Recovery: GABA Agonism Restores Neural Variability in Older, Poorer Performing Adults.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Trial
- Recovery from disorders of consciousness: Lesions and GABAergic modulation in a biologically inspired spiking neural network.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Inter-regional interactions uncouple within-region inhibition stabilization and paradoxical responses.bioRxiv : the preprint server for biology · 2026Article
- What Dale never said: multiple incarnations of Dale's law from the birth of pharmacology to modeling brain circuits.Journal of neurophysiology · 2026Review
- Article
- Anti-Seizure Medications Alter Functional and Effective Connectivity as Measured With Intracranial Electroencephalography.Brain and behavior · 2026Article
- Intrinsic space-time couplings governing multi-scale cortical dynamics.bioRxiv : the preprint server for biology · 2026Article
- Multiplexed changes in synaptic transmission underlie stress-induced reduction of persistent firing in the parietal cortex.Progress in neurobiology · 2026Article
- Global neural oscillations underlie performance variability and attentional state fluctuations in humans.Scientific reports · 2026Article
- Astrocyte-mediated higher-order control of synaptic plasticity.Communications biology · 2026Article
- Laminar-specific control of response gain and orientation-tuning by parvalbumin-expressing inhibitory interneurons in primate visual cortex.Research square · 2026Article
- Article
- Data-derived agents reveal dynamical reservoirs in mouse cortex for adaptive behavior.bioRxiv : the preprint server for biology · 2026Article
- Characteristics and dynamical signatures of recurrent cortical circuits during context-dependent processing.bioRxiv : the preprint server for biology · 2026Article
- Sexually dimorphic plasticity of PV inhibition in sensory neocortex during learning.Scientific reports · 2026Article
- Tuning excitatory input to fast-spiking parvalbumin-positive interneurons: a lever for plasticity and hyperexcitability across the lifespan.Frontiers in synaptic neuroscience · 2026Article
- Can we infer excitation-inhibition balance from the spectrum of population activity?Communications biology · 2025Article
- Inhibition mediated by group III metabotropic glutamate receptors regulates habenula activity and defensive behaviors.Nature communications · 2025Article
- Stable recurrent dynamics in heterogeneous neuromorphic computing systems using excitatory and inhibitory plasticity.Nature communications · 2025Article
- Excitation-inhibition balance abnormally shapes structure-function coupling of gray matter in Parkinson's disease.NPJ Parkinson's disease · 2025Review
18 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuronal networks with strong recurrent connectivity provide the brain with a powerful means to perform complex computational tasks. However, high-gain excitatory networks are susceptible to instability, which can lead to runaway activity, as manifested in pathological regimes such as epilepsy. Inhibitory stabilization offers a dynamic, fast and flexible compensatory mechanism to balance otherwise unstable networks, thus enabling the brain to operate in its most efficient regimes. Here we review recent experimental evidence for the presence of such inhibition-stabilized dynamics in the brain and discuss their consequences for cortical computation. We show how the study of inhibition-stabilized networks in the brain has been facilitated by recent advances in the technological toolbox and perturbative techniques, as well as a concomitant development of biologically realistic computational models. By outlining future avenues, we suggest that inhibitory stabilization can offer an exemplary case of how experimental neuroscience can progress in tandem with technology and theory to advance our understanding of the brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.