Evidence map›Paper›PMID 33177623›Full record

ArticleScientific reports2020

Complement C6 deficiency exacerbates pathophysiology after spinal cord injury.

Diane Su, Mitra J Hooshmand, Manuel D Galvan, Rebecca A Nishi, Brian J Cummings, Aileen J Anderson

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Diane SuDepartment of Anatomy and Neurobiology, University of California, Irvine, Irvine, CA, USA.
Mitra J HooshmandDepartment of Anatomy and Neurobiology, University of California, Irvine, Irvine, CA, USA.
Manuel D GalvanDepartment of Anatomy and Neurobiology, University of California, Irvine, Irvine, CA, USA.
Rebecca A NishiSue and Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, CA, USA.
Brian J CummingsDepartment of Anatomy and Neurobiology, University of California, Irvine, Irvine, CA, USA.
Aileen J AndersonDepartment of Anatomy and Neurobiology, University of California, Irvine, Irvine, CA, USA. aja@uci.edu.
University of California, Irvine · US

Funding

Mechanisms of Complement-Mediated Damage in SCIR01NS043428 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI ANDERSON, AILEEN J · 2003 to 2007
$1.8M
NINDS NIH HHS NS43428-01NINDS NIH HHS R01 NS043428
6 · The paper itself

Abstract

Historically, the membrane attack complex, composed of complement components C5b-9, has been connected to lytic cell death and implicated in secondary injury after a CNS insult. However, studies to date have utilized either non-littermate control rat models, or mouse models that lack significant C5b-9 activity. To investigate what role C5b-9 plays in spinal cord injury and recovery, we generated littermate PVG C6 wildtype and deficient rats and tested functional and histological recovery after moderate contusion injury using the Infinite Horizon Impactor. We compare the effect of C6 deficiency on recovery of locomotor function and histological injury parameters in PVG rats under two conditions: (1) animals maintained as separate C6 WT and C6-D homozygous colonies; and (2) establishment of a heterozygous colony to generate C6 WT and C6-D littermate controls. The results suggest that maintenance of separate homozygous colonies is inadequate for testing the effect of C6 deficiency on locomotor and histological recovery after SCI, and highlight the importance of using littermate controls in studies involving genetic manipulation of the complement cascade.

Indexed as

AnimalsBehavior, AnimalComplement C6Complement Membrane Attack ComplexDisease Models, AnimalFemaleGenotypeGlial Fibrillary Acidic ProteinGray MatterHereditary Complement Deficiency DiseasesHeterozygoteLocomotionMaleMyelin Basic ProteinRats, Mutant StrainsSelective BreedingComplement C6Complement Membrane Attack ComplexGlial Fibrillary Acidic ProteinMyelin Basic Protein

Identifiers

PMID33177623
PMCPMC7659012
OpenAlexW3098548658

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.