ArticleThe ISME journal2021
Plant resistome profiling in evolutionary old bog vegetation provides new clues to understand emergence of multi-resistance.
Article in The ISME journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 58 citations in OpenAlex.
- Phenotypic resistance profiles and resistome variations between endophytic and epiphytic bacteria in apple fruits.Environmental microbiome · 2026Article
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- Soil antibiotic resistome in farmland exhibits higher diversity and horizontal transfer potential than adjacent pastureland in agro-pastoral ecotone.Environmental microbiome · 2026Article
- Diversity and selected functional traits of microbiota associated with traditional dried plant foods from South African informal markets.FEMS microbes · 2026Article
- AI-driven virtual cell models in preclinical research: technical pathways, validation mechanisms, and clinical translation potential.NPJ digital medicine · 2025Review
- Resistance in gram-negative bacilli: the emergence of RND efflux pumps.Future microbiology · 2025Review
- Microbiome Literacy: Enhancing Public and Academic Understanding Through the 'Microbiome & Health' Online Course.Microbial biotechnology · 2025Article
- Unde venis? Bacterial resistance from environmental reservoirs to lettuce: tracking microbiome and resistome over a growth period.FEMS microbiology ecology · 2024Article
- Protistan predation selects for antibiotic resistance in soil bacterial communities.The ISME journal · 2023Article
- Functional analysis of bacterial genes accidentally packaged in rhizospheric phageome of the wild plant speciesSaudi journal of biological sciences · 2023Article
- Abundant resistome determinants in rhizosphere soil of the wild plant Abutilon fruticosum.AMB Express · 2023Article
- ResFinderFG v2.0: a database of antibiotic resistance genes obtained by functional metagenomics.Nucleic acids research · 2023Article
- [Health risks from crop irrigation with treated wastewater containing antibiotic residues, resistance genes, and resistant microorganisms].Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2023Review
- Adaptation of Rhizosphere Microbial Communities to Continuous Exposure to Multiple Residual Antibiotics in Vegetable Farms.International journal of environmental research and public health · 2023Article
- Functional annotation of rhizospheric phageome of the wild plant speciesFrontiers in microbiology · 2023Article
- Phyllosphere-associated microbiota in built environment: Do they have the potential to antagonize human pathogens?Journal of advanced research · 2023Article
- The global distribution and environmental drivers of the soil antibiotic resistome.Microbiome · 2022Article
- Metadata harmonization-Standards are the key for a better usage of omics data for integrative microbiome analysis.Environmental microbiome · 2022Article
- The plant microbiota signature of the Anthropocene as a challenge for microbiome research.Microbiome · 2022Review
- The microbiome and resistome of apple fruits alter in the post-harvest period.Environmental microbiome · 2022Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The expanding antibiotic resistance crisis calls for a more in depth understanding of the importance of antimicrobial resistance genes (ARGs) in pristine environments. We, therefore, studied the microbiome associated with Sphagnum moss forming the main vegetation in undomesticated, evolutionary old bog ecosystems. In our complementary analysis of culture collections, metagenomic data and a fosmid library from different geographic sites in Europe, we identified a low abundant but highly diverse pool of resistance determinants, which targets an unexpectedly broad range of 29 antibiotics including natural and synthetic compounds. This derives both, from the extraordinarily high abundance of efflux pumps (up to 96%), and the unexpectedly versatile set of ARGs underlying all major resistance mechanisms. Multi-resistance was frequently observed among bacterial isolates, e.g. in Serratia, Rouxiella, Pandoraea, Paraburkholderia and Pseudomonas. In a search for novel ARGs, we identified the new class A β-lactamase Mm3. The native Sphagnum resistome comprising a highly diversified and partially novel set of ARGs contributes to the bog ecosystem´s plasticity. Our results reinforce the ecological link between natural and clinically relevant resistomes and thereby shed light onto this link from the aspect of pristine plants. Moreover, they underline that diverse resistomes are an intrinsic characteristic of plant-associated microbial communities, they naturally harbour many resistances including genes with potential clinical relevance.
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