Evidence map›Paper›PMID 33177587›Full record

ArticleScientific reports2020

Oxidative stress induced by the anti-cancer agents, plumbagin, and atovaquone, inhibits ion transport through Na

Yousef Alharbi, Arvinder Kapur, Mildred Felder, Lisa Barroilhet, Bikash R Pattnaik, Manish S Patankar

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.2field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Metabolic starvation-induced cell swelling drives solid stress in tumors.bioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. NaInternational journal of molecular sciences · 2024
    Review
  5. Article
  6. Article
  7. Apigeninidin chloride disruptsFrontiers in cellular and infection microbiology · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Yousef AlharbiDepartment of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, WI, 53792, USA.
Arvinder KapurDepartment of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, WI, 53792, USA.
Mildred FelderDepartment of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, WI, 53792, USA.
Lisa BarroilhetDepartment of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, WI, 53792, USA.
Bikash R PattnaikDepartment of Pediatrics, Ophthalmology and Visual Sciences, McPherson Eye Research Institute, University of Wisconsin-Madison, Madison, WI, 53706, USA. pattnaik@wisc.edu.
Manish S PatankarDepartment of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, WI, 53792, USA. patankar@wisc.edu.
University of Wisconsin–Madison · USQassim University · SASmith-Kettlewell Eye Research Institute · US

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Christian Capitini · 1985 to 2026
$142.6M
Repurposing Atovaquone for Preventing Ovarian Cancer: An Example of Successful Inhibition of Oxidative PhosphorylationR01CA238423 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI BARROILHET, LISA M · 2020 to 2024
$1.5M
NCI NIH HHS P30 CA014520NCI NIH HHS R01 CA238423NIH HHS EY024995-BRP
6 · The paper itself

Abstract

Oxidative stress inhibits Na

Indexed as

Adenosine TriphosphateAnimalsAntineoplastic Agents, PhytogenicAtovaquoneCell Line, TumorCell ProliferationEnzyme InhibitorsFemaleHumansIon TransportMiceNaphthoquinonesOvarian NeoplasmsOxidative StressPatch-Clamp TechniquesSodium-Potassium-Exchanging ATPaseAdenosine TriphosphateAntineoplastic Agents, PhytogenicAtovaquoneEnzyme InhibitorsNaphthoquinonesplumbaginSodium-Potassium-Exchanging ATPase

Identifiers

PMID33177587
PMCPMC7659016
OpenAlexW3100033006

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.