Evidence map›Paper›PMID 33177235›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Type 1 interferon-dependent repression of NLRC4 and iPLA2 licenses down-regulation of

Ajay Suresh Akhade, Shaikh M Atif, Bhavana S Lakshmi, Neha Dikshit, Kelly T Hughes, Ayub Qadri, Naeha Subramanian

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Exposing the Two Contrasting Faces of STAT2 in Inflammation.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2022
    Review
  10. Intratumoral injection of schwannoma with attenuatedProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  11. Frontiers in immunology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Ajay Suresh AkhadeInstitute for Systems Biology, Seattle, WA 98109.ORCID 0000-0002-0803-2416
Shaikh M AtifHybridoma Laboratory, National Institute of Immunology, 110067 New Delhi, India.
Bhavana S LakshmiInstitute for Systems Biology, Seattle, WA 98109.
Neha DikshitHybridoma Laboratory, National Institute of Immunology, 110067 New Delhi, India.
Kelly T HughesDepartment of Biology, University of Utah, Salt Lake City, UT 84112.ORCID 0000-0001-5344-0972
Ayub QadriHybridoma Laboratory, National Institute of Immunology, 110067 New Delhi, India; ayub@nii.ac.in nsubrama@systemsbiology.org.ORCID 0000-0001-5870-8034
Naeha SubramanianInstitute for Systems Biology, Seattle, WA 98109; ayub@nii.ac.in nsubrama@systemsbiology.org.ORCID 0000-0003-3754-0521
National Institute of Immunology · INInstitute for Systems Biology · USUniversity of Utah · USUniversity of Washington · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammasomes have been implicated in the detection and clearance of a variety of bacterial pathogens, but little is known about whether this innate sensing mechanism has any regulatory effect on the expression of stimulatory ligands by the pathogen. During infection with

Indexed as

Adaptor Proteins, Vesicular TransportAnimalsApoptosis Regulatory ProteinsCalcium-Binding ProteinsCells, CulturedDisease Models, AnimalDown-RegulationFlagellinGroup VI Phospholipases A2HumansImmunity, InnateInflammasomesInterferon Type IKetonesLipopolysaccharidesLysophospholipids1,1,1-trifluoro-6-(naphthalen-2-yl)hexan-2-oneAdaptor Proteins, Vesicular TransportApoptosis Regulatory ProteinsCalcium-Binding ProteinsFlagellinGroup VI Phospholipases A2InflammasomesInterferon Type IIpaf protein, mouseKetonesLipopolysaccharidesLysophospholipidsNaphthalenesPla2g6 protein, mouseTicam1 protein, mouseflagellininflammasomeNLRC4Salmonellatype 1 interferon

Identifiers

PMID33177235
PMCPMC7703570
OpenAlexW3106482683

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.