Evidence map›Paper›PMID 33177224›Full record

ArticleNeurology2020

New onset of restless legs syndrome in pregnancy in a prospective multiracial cohort: Incidence and risk factors.

Muzi Na, Jing Wu, Mengying Li, Stefanie N Hinkle, Cuilin Zhang, Xiang Gao

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Vitamin D deficiency and restless legs syndrome during pregnancy: walking in sunshine?Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2023
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Muzi NaFrom the Department of Nutritional Sciences (M.N., X.G.), the Pennsylvania State University, University Park; Glotech Inc (J.W.), Rockville, MD; and Epidemiology Branch (M.L., S.N.H., C.Z.), Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD.ORCID 0000-0002-8844-0646
Jing WuFrom the Department of Nutritional Sciences (M.N., X.G.), the Pennsylvania State University, University Park; Glotech Inc (J.W.), Rockville, MD; and Epidemiology Branch (M.L., S.N.H., C.Z.), Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD.
Mengying LiFrom the Department of Nutritional Sciences (M.N., X.G.), the Pennsylvania State University, University Park; Glotech Inc (J.W.), Rockville, MD; and Epidemiology Branch (M.L., S.N.H., C.Z.), Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD.
Stefanie N HinkleFrom the Department of Nutritional Sciences (M.N., X.G.), the Pennsylvania State University, University Park; Glotech Inc (J.W.), Rockville, MD; and Epidemiology Branch (M.L., S.N.H., C.Z.), Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD.
Cuilin ZhangFrom the Department of Nutritional Sciences (M.N., X.G.), the Pennsylvania State University, University Park; Glotech Inc (J.W.), Rockville, MD; and Epidemiology Branch (M.L., S.N.H., C.Z.), Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD. zhangcu@mail.nih.gov xxg14@psu.edu.
Xiang GaoFrom the Department of Nutritional Sciences (M.N., X.G.), the Pennsylvania State University, University Park; Glotech Inc (J.W.), Rockville, MD; and Epidemiology Branch (M.L., S.N.H., C.Z.), Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD. zhangcu@mail.nih.gov xxg14@psu.edu.ORCID 0000-0003-2617-6509
Pennsylvania State University · US

Funding

NICHD NIH HHS HHSN275200800002INICHD NIH HHS HHSN275200800012CNICHD NIH HHS HHSN275200800013CNICHD NIH HHS HHSN275200800014CNICHD NIH HHS HHSN275200800028CNICHD NIH HHS HHSN275201000001ZNICHD NIH HHS HHSN275201000009C
6 · The paper itself

Abstract

objectiveTo determine whether the incidence and risk factors of restless legs syndrome (RLS) in pregnancy differ by race/ethnicity, we estimated relative risks of demographic, socioeconomic, and nutritional factors in association with risk of any incident RLS in pregnancy in a cohort of 2,704 healthy pregnant women without prior RLS.

methodsUsing data from the multicenter, multiracial National Institute of Child Health and Human Development (NICHD) Fetal Growth Studies-Singletons, we examined the incidence of RLS from early pregnancy to near delivery through up to 6 assessments. Multivariable Poisson models with robust variance were applied to estimate relative risks (RRs).

resultsThe cumulative incidence of RLS in pregnancy was 18.1% for all women, 20.3% for White women, 15.4% for Black women, 17.1% for Hispanic women, and 21.1% for Asian women. Among Hispanic women, older age (RR [reference ≤25 years]: 25-35 years, 1.51; 95% confidence interval [CI] 1.05-2.16; ≥35 years, 1.58; 95% CI 0.93-2.68), anemia (RR [reference no]: yes, 2.47; 95% CI 1.31-4.64), and greater total skinfolds of the subscapular and triceps sites, independent of body mass index (RR [reference quartile 1]: quartile 5, 2.54; 95% CI 1.30-4.97;

conclusionsThe incidence of RLS in pregnancy was high and differed by race/ethnicity, which is likely accounted for by differences in other risk factors, such as age, parity, and nutritional factors.

Indexed as

AdultAge FactorsAsianBlack or African AmericanBody Mass IndexFemaleHispanic or LatinoHumansIncidencePregnancyPregnancy ComplicationsProspective StudiesRestless Legs SyndromeRisk FactorsUnited StatesWhite People

Identifiers

PMID33177224
PMCPMC7836662
OpenAlexW3098954811

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.