Evidence map›Paper›PMID 33177222›Full record

ArticleNeurology2021

REM Sleep Behavior Disorder in Children With Type 1 Narcolepsy Treated With Sodium Oxybate.

Elena Antelmi, Marco Filardi, Fabio Pizza, Stefano Vandi, Monica Moresco, Christian Franceschini, Michele Tinazzi, Raffaele Ferri, Giuseppe Plazzi

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Management of REM sleep behavior disorder: an American Academy of Sleep Medicine systematic review, meta-analysis, and GRADE assessment.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2023
    Pooled it
  2. Trial
  3. Narcolepsy and rapid eye movement sleep.Journal of sleep research · 2025
    Review
  4. Article
  5. Effects of bupropion and SSRI antidepressants on leg movement activity and chin muscle tone during sleep in adolescents.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2023
    Article
  6. Review
  7. Rapid Eye Movement Sleep during Early Life: A Comprehensive Narrative Review.International journal of environmental research and public health · 2022
    Review
  8. Current Treatment Options for REM Sleep Behaviour Disorder.Journal of personalized medicine · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Elena AntelmiFrom the Neurology Unit (E.A., M.T.), Movement Disorders Division, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona; Department of Biomedical and Neuromotor Sciences (E.A., M.F., F.P., M.M., G.P.), University of Bologna; IRCCS (F.P., S.V., G.P.), Istituto delle Scienze Neurologiche di Bologna; Department of Medicine and Surgery (C.F.), University of Parma; and Sleep Research Centre (R.F.), Department of Neurology IC, Oasi Research institute-IRCCS, Troina, Italy.
Marco FilardiFrom the Neurology Unit (E.A., M.T.), Movement Disorders Division, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona; Department of Biomedical and Neuromotor Sciences (E.A., M.F., F.P., M.M., G.P.), University of Bologna; IRCCS (F.P., S.V., G.P.), Istituto delle Scienze Neurologiche di Bologna; Department of Medicine and Surgery (C.F.), University of Parma; and Sleep Research Centre (R.F.), Department of Neurology IC, Oasi Research institute-IRCCS, Troina, Italy.
Fabio PizzaFrom the Neurology Unit (E.A., M.T.), Movement Disorders Division, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona; Department of Biomedical and Neuromotor Sciences (E.A., M.F., F.P., M.M., G.P.), University of Bologna; IRCCS (F.P., S.V., G.P.), Istituto delle Scienze Neurologiche di Bologna; Department of Medicine and Surgery (C.F.), University of Parma; and Sleep Research Centre (R.F.), Department of Neurology IC, Oasi Research institute-IRCCS, Troina, Italy.
Stefano VandiFrom the Neurology Unit (E.A., M.T.), Movement Disorders Division, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona; Department of Biomedical and Neuromotor Sciences (E.A., M.F., F.P., M.M., G.P.), University of Bologna; IRCCS (F.P., S.V., G.P.), Istituto delle Scienze Neurologiche di Bologna; Department of Medicine and Surgery (C.F.), University of Parma; and Sleep Research Centre (R.F.), Department of Neurology IC, Oasi Research institute-IRCCS, Troina, Italy.
Monica MorescoFrom the Neurology Unit (E.A., M.T.), Movement Disorders Division, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona; Department of Biomedical and Neuromotor Sciences (E.A., M.F., F.P., M.M., G.P.), University of Bologna; IRCCS (F.P., S.V., G.P.), Istituto delle Scienze Neurologiche di Bologna; Department of Medicine and Surgery (C.F.), University of Parma; and Sleep Research Centre (R.F.), Department of Neurology IC, Oasi Research institute-IRCCS, Troina, Italy.
Christian FranceschiniFrom the Neurology Unit (E.A., M.T.), Movement Disorders Division, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona; Department of Biomedical and Neuromotor Sciences (E.A., M.F., F.P., M.M., G.P.), University of Bologna; IRCCS (F.P., S.V., G.P.), Istituto delle Scienze Neurologiche di Bologna; Department of Medicine and Surgery (C.F.), University of Parma; and Sleep Research Centre (R.F.), Department of Neurology IC, Oasi Research institute-IRCCS, Troina, Italy.
Michele TinazziFrom the Neurology Unit (E.A., M.T.), Movement Disorders Division, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona; Department of Biomedical and Neuromotor Sciences (E.A., M.F., F.P., M.M., G.P.), University of Bologna; IRCCS (F.P., S.V., G.P.), Istituto delle Scienze Neurologiche di Bologna; Department of Medicine and Surgery (C.F.), University of Parma; and Sleep Research Centre (R.F.), Department of Neurology IC, Oasi Research institute-IRCCS, Troina, Italy.
Raffaele FerriFrom the Neurology Unit (E.A., M.T.), Movement Disorders Division, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona; Department of Biomedical and Neuromotor Sciences (E.A., M.F., F.P., M.M., G.P.), University of Bologna; IRCCS (F.P., S.V., G.P.), Istituto delle Scienze Neurologiche di Bologna; Department of Medicine and Surgery (C.F.), University of Parma; and Sleep Research Centre (R.F.), Department of Neurology IC, Oasi Research institute-IRCCS, Troina, Italy.ORCID 0000-0001-6937-3065
Giuseppe PlazziFrom the Neurology Unit (E.A., M.T.), Movement Disorders Division, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona; Department of Biomedical and Neuromotor Sciences (E.A., M.F., F.P., M.M., G.P.), University of Bologna; IRCCS (F.P., S.V., G.P.), Istituto delle Scienze Neurologiche di Bologna; Department of Medicine and Surgery (C.F.), University of Parma; and Sleep Research Centre (R.F.), Department of Neurology IC, Oasi Research institute-IRCCS, Troina, Italy. giuseppe.plazzi@unibo.it.
University of Parma · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo study the effect of stable treatment with sodium oxybate (SO) on nocturnal REM sleep behavior disorder (RBD) and REM sleep without atonia (RSWA) that severely affected children with type 1 narcolepsy (NT1).

methodsNineteen children and adolescents with NT1 (9 female, mean age 12.5 ± 2.7 years, mean disease duration 3.4 ± 1.6 years) underwent neurologic investigations and video-polysomnography (v-PSG) at baseline and after 3 months of stable treatment with SO. v-PSG was independently analyzed by 2 sleep experts to rate RBD episodes. RSWA was automatically computed by means of the validated REM sleep atonia index (RAI).

resultsCompared to baseline, RAI significantly improved (

conclusionsRBD and RSWA improved after treatment with SO, pointing to a direct role of the drug in modulating motor control during REM sleep. CLASSIFICATION OF EVIDENCE: This study offers Class IV evidence of the positive effect of SO on modulation of muscle atonia during REM sleep in children with NT1 because of the absence of a control group.

Indexed as

Adjuvants, AnesthesiaAdolescentChildCohort StudiesFemaleHumansMaleNarcolepsyPolysomnographyREM Sleep Behavior DisorderSleep, REMSodium OxybateTreatment OutcomeAdjuvants, AnesthesiaSodium Oxybate

Identifiers

PMID33177222
PMCPMC7905776
OpenAlexW3105093613

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.