Evidence map›Paper›PMID 33177207›Full record

ArticleJournal of virology2021

CD300lf Conditional Knockout Mouse Reveals Strain-Specific Cellular Tropism of Murine Norovirus.

Vincent R Graziano, Mia Madel Alfajaro, Cameron O Schmitz, Renata B Filler, Madison S Strine, Jin Wei, Leon L Hsieh, Megan T Baldridge, Timothy J Nice, Sanghyun Lee and 2 more

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Vincent R GrazianoDepartment of Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Mia Madel AlfajaroDepartment of Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Cameron O SchmitzDepartment of Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Renata B FillerDepartment of Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Madison S StrineDepartment of Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Jin WeiDepartment of Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Leon L HsiehDepartment of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
Megan T BaldridgeDepartment of Medicine, Division of Infectious Diseases, Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine, Saint Louis, Missouri, USA.ORCID 0000-0002-7030-6131
Timothy J NiceDepartment of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon, USA.ORCID 0000-0002-4471-7666
Sanghyun LeeDepartment of Molecular Microbiology and Immunology, Brown University, Providence, Rhode Island, USA.
Robert C OrchardDepartment of Immunology, University of Texas Southwestern Medical School, Dallas, Texas, USA.
Craig B WilenDepartment of Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut, USA craig.wilen@yale.edu.ORCID 0000-0003-2495-9403
Yale University · USBrown University · USJohns Hopkins University · USOregon Health & Science University · USThe University of Texas Southwestern Medical Center · USWashington University in St. Louis · US

Funding

INTERDISCIPLINARY IMMUNOLOGY TRAINING PROGRAMT32AI007019 · NIAID · YALE UNIVERSITY · PI Carrie L. Lucas, David G. Schatz · 1985 to 2026
$14.4M
The role of tuft cells in norovirus pathogenesisR01AI148467 · NIAID · YALE UNIVERSITY · PI Craig Brian Wilen · 2020 to 2026
$3.9M
Role of CD300 Family in Norovirus Tropism, Persistence, and ImmunityR01AI127552 · NIAID · WASHINGTON UNIVERSITY · PI BALDRIDGE, MEGAN T, FREMONT, DAVED H. · 2017 to 2021
$3.5M
Norovirus regulation via bacterial modulation of interferon-lambdaR01AI139314 · NIAID · WASHINGTON UNIVERSITY · PI BALDRIDGE, MEGAN T · 2019 to 2023
$2.0M
Role of virus-receptor interactions in determining norovirus tropism and pathogenesis in vivoK08AI128043 · NIAID · YALE UNIVERSITY · PI WILEN, CRAIG BRIAN · 2017 to 2021
$940k
Identification and Characterization of Norovirus Cofactors for EntryR00DK116666 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI ORCHARD, ROBERT C. · 2018 to 2020
$747k
NIAID NIH HHS K08 AI128043NIAID NIH HHS R01 AI127552NIAID NIH HHS R01 AI139314NIAID NIH HHS R01 AI148467NIAID NIH HHS T32 AI007019NIDDK NIH HHS R00 DK116666
6 · The paper itself

Abstract

Noroviruses are a leading cause of gastrointestinal infection in humans and mice. Understanding human norovirus (HuNoV) cell tropism has important implications for our understanding of viral pathogenesis. Murine norovirus (MNoV) is extensively used as a surrogate model for HuNoV. We previously identified CD300lf as the receptor for MNoV. Here, we generated a

Indexed as

Host-Pathogen InteractionsViral TropismAnimalsCaliciviridae InfectionsEpithelial CellsFemaleImmunity, InnateIntestinesMaleMiceMice, KnockoutNorovirusReceptors, ImmunologicCLM-1 protein, mouseReceptors, ImmunologicCD300lfcell tropismnorovirusviral entry

Identifiers

PMID33177207
PMCPMC7925115
OpenAlexW3105022111

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.