Evidence map›Paper›PMID 33177204›Full record

ArticleJournal of virology2021

Deep Gene Sequence Cluster Analyses of Multi-Virus-Infected Mucosal Tissue Reveal Enhanced Transmission of Acute HIV-1.

Katja Klein, Immaculate Nankya, Gabrielle Nickel, Annette N Ratcliff, Adam A J Meadows, Nicholas Hathaway, Jeffrey A Bailey, Daniel J Stieh, Hannah M Cheeseman, Ann M Carias and 6 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Mucosal immunity in acute HIV: a review of recent work.Current opinion in HIV and AIDS · 2025
    Review
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 8 institutions in 4 countries.

Katja KleinDepartment of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada kklein5@uwo.ca earts@uwo.ca.
Immaculate NankyaJoint Clinical Research Centre, Kampala, Uganda.
Gabrielle NickelDepartment of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Annette N RatcliffDepartment of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Adam A J MeadowsDepartment of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada.
Nicholas HathawayDepartment of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Jeffrey A BaileyWarren Alpert Medical School, Brown University, Providence, Rhode Island, USA.
Daniel J StiehDepartment of Cellular and Molecular Medicine, St. George's, University of London, London, United Kingdom.
Hannah M CheesemanDepartment of Medicine, Imperial College London, London, United Kingdom.
Ann M CariasDepartment of Cellular and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Michael A LobritzDepartment of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Jamie F S MannDepartment of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada.
Yong GaoDepartment of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada.
Thomas J HopeDepartment of Cellular and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.ORCID 0000-0001-7183-8319
Robin J ShattockDepartment of Cellular and Molecular Medicine, St. George's, University of London, London, United Kingdom.
Eric J ArtsDepartment of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada kklein5@uwo.ca earts@uwo.ca.ORCID 0000-0002-4880-7968
Western University · CACase Western Reserve University · USNorthwestern University · USSt George's, University of London · GBBrown University · USImperial College London · GBJoint Clinical Research Centre · UGUniversity of Massachusetts Chan Medical School · US

Funding

WG3: HIV, Co-infections and Co-morbiditiesP30AI036219 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI Alan David Levine · 1994 to 2026
$50.0M
Virus TransmissionP50AI150464 · NIAID · UNIVERSITY OF UTAH · PI SUNDQUIST, WESLEY I. · 2019 to 2021
$14.9M
Impact of HIV-1 Fitness on Disease ProgressionR01AI049170 · NIAID · UNIVERSITY OF WESTERN ONTARIO · PI ARTS, ERIC J · 2002 to 2024
$6.8M
HIV-1 Fitness and RecombinationR56AI049170 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI ARTS, ERIC J · 2012 to 2012
$400k
Impact of HIV-1 Fitness on Disease ProgressionR21AI049170 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI ARTS, ERIC J · 2001 to 2001
$265k
NIAID NIH HHS P30 AI036219NIAID NIH HHS P50 AI150464NIAID NIH HHS R01 AI049170NIAID NIH HHS R21 AI049170NIAID NIH HHS R56 AI049170
6 · The paper itself

Abstract

Exposure of the genital mucosa to a genetically diverse viral swarm from the donor HIV-1 can result in breakthrough and systemic infection by a single transmitted/founder (TF) virus in the recipient. The highly diverse HIV-1 envelope (Env) in this inoculating viral swarm may have a critical role in transmission and subsequent immune response. Thus, chronic (Env

Indexed as

Cervix UteriFemaleHigh-Throughput Nucleotide SequencingHIV-1HIV InfectionsHumansLeukocytes, MononuclearMaleMucous MembranePenisRNA, ViralViral ProteinsRNA, ViralViral ProteinsfitnessHIVtransmission

Identifiers

PMID33177204
PMCPMC7925087
OpenAlexW3102511291

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.