Evidence map›Paper›PMID 33177180›Full record

ArticleScience translational medicine2020

Regulatory T cells engineered with TCR signaling-responsive IL-2 nanogels suppress alloimmunity in sites of antigen encounter.

Siawosh K Eskandari, Ina Sulkaj, Mariane B Melo, Na Li, Hazim Allos, Juliano B Alhaddad, Branislav Kollar, Thiago J Borges, Arach S Eskandari, Max A Zinter and 15 more

Open access · greenAbstract read
In one paragraph

Article in Science translational medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 96 citations in OpenAlex.

  1. Biomaterial-EnabledCell biomaterials · 2026
    Article
  2. Review
  3. Regulatory T cells in cancer and inflammation.Signal transduction and targeted therapy · 2026
    Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. [Biomaterials of different sizes for enhanced adoptive cell transfer therapy in solid tumors].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2025
    Review
  9. Unlocking Transplant Tolerance with Biomaterials.Advanced healthcare materials · 2025
    Review
  10. Review
  11. Article
  12. Article
  13. CAR T Cell Nanosymbionts: Revealing the Boundless Potential of a New Dyad.International journal of molecular sciences · 2024
    Review
  14. Cell-drug conjugates.Nature biomedical engineering · 2024
    Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

25 authors at 7 institutions in 3 countries.

Siawosh K EskandariTransplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0003-4867-4170
Ina SulkajTransplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-2494-8942
Mariane B MeloKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.ORCID 0000-0002-0409-2454
Na LiKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
Hazim AllosTransplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0001-7335-9098
Juliano B AlhaddadTransplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-1461-7955
Branislav KollarDivision of Plastic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0001-6668-7798
Thiago J BorgesTransplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-6554-0169
Arach S EskandariDepartment of Electrical Engineering, Delft University of Technology, 2628 CD Delft, Netherlands.
Max A ZinterExperimental Therapeutics and Molecular Imaging Unit, Department of Neurology, Neuro-Oncology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA.
Songjie CaiTransplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-8166-4356
Jean Pierre AssakerTransplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-4943-6441
John Y ChoiTransplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-9299-3921
Basmah S Al DulaijanTransplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0001-8007-359X
Amr MansouriTransplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-7095-4091
Yousef HaikTransplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-3665-7456
Bakhos A TannousExperimental Therapeutics and Molecular Imaging Unit, Department of Neurology, Neuro-Oncology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA.ORCID 0000-0001-7062-0684
Willem J van SonDivision of Nephrology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, Netherlands.
Henri G D LeuveninkDepartment of Surgery, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, Netherlands.ORCID 0000-0001-5036-2999
Bohdan PomahacDivision of Plastic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Leonardo V RiellaTransplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Li TangInstitute of Bioengineering, École Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.ORCID 0000-0002-6393-982X
Marc A J SeelenDivision of Nephrology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, Netherlands.
Darrell J IrvineKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA. djirvine@mit.edu jazzi@bwh.harvard.edu.ORCID 0000-0002-8637-1405
Jamil R AzziTransplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. djirvine@mit.edu jazzi@bwh.harvard.edu.ORCID 0000-0002-6909-4645
Brigham and Women's Hospital · USUniversity Medical Center Groningen · NLHarvard University · USMassachusetts Institute of Technology · USDelft University of Technology · NLÉcole Polytechnique Fédérale de Lausanne · CHHoward Hughes Medical Institute · US

Funding

TRAINING PROGRAM IN ACADEMIC NEPHROLOGYT32DK007527 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI BONVENTRE, JOSEPH VINCENT · 1986 to 2021
$8.8M
The novel role of the immunoproteasome subunit LMP7 in allo-immunity and T cell exhaustionR01AI134842 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI AZZI, JAMIL · 2018 to 2022
$1.9M
NIAID NIH HHS R01 AI134842NIDDK NIH HHS T32 DK007527
6 · The paper itself

Abstract

Adoptive cell transfer of ex vivo expanded regulatory T cells (T

Indexed as

Interleukin-2T-Lymphocytes, RegulatoryAnimalsMiceNanogelsReceptors, Antigen, T-CellSignal TransductionInterleukin-2NanogelsReceptors, Antigen, T-Cell

Identifiers

PMID33177180
PMCPMC8519505
OpenAlexW3102422330

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.