Evidence map›Paper›PMID 33177105›Full record

ArticleScience (New York, N.Y.)2021

Seroprevalence of anti-SARS-CoV-2 IgG antibodies in Kenyan blood donors.

Sophie Uyoga, Ifedayo M O Adetifa, Henry K Karanja, James Nyagwange, James Tuju, Perpetual Wanjiku, Rashid Aman, Mercy Mwangangi, Patrick Amoth, Kadondi Kasera and 29 more

Open access · hybridAbstract read
In one paragraph

Article in Science (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 202 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
202citing papers in PubMed, 4 pooled it
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

202 citing papers in PubMed, 4 syntheses or guidelines pooled it, 349 citations in OpenAlex.

  1. Seroprevalence of SARS-CoV-2 Antibodies in Africa: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022
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  18. Rethinking the evidence on COVID-19 in Africa.The Lancet. Infectious diseases · 2025
    Review
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142 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

39 authors at 6 institutions in 2 countries.

Sophie Uyoga *KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya. suyoga@kemri-wellcome.org.ORCID https://orcid.org/0000-0003-1746-7873
Ifedayo M O Adetifa *KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.ORCID https://orcid.org/0000-0003-2556-9407
Henry K Karanja *KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.ORCID https://orcid.org/0000-0002-8249-6833
James Nyagwange *KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.ORCID https://orcid.org/0000-0001-5430-6011
James TujuKEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.ORCID https://orcid.org/0000-0002-0624-1791
Perpetual WanjikuKEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.ORCID https://orcid.org/0000-0001-9293-0181
Rashid AmanMinistry of Health, Government of Kenya, Nairobi, Kenya.
Mercy MwangangiMinistry of Health, Government of Kenya, Nairobi, Kenya.
Patrick AmothMinistry of Health, Government of Kenya, Nairobi, Kenya.
Kadondi KaseraMinistry of Health, Government of Kenya, Nairobi, Kenya.ORCID https://orcid.org/0000-0003-0551-7968
Wangari Ng'ang'aPresidential Policy and Strategy Unit, The Presidency, Government of Kenya, Nairobi, Kenya.ORCID https://orcid.org/0000-0003-1440-0921
Charles RomboKenya National Blood Transfusion Services, Ministry of Health, Nairobi, Kenya.
Christine YegonKenya National Blood Transfusion Services, Ministry of Health, Nairobi, Kenya.
Khamisi KithiKenya National Blood Transfusion Services, Ministry of Health, Nairobi, Kenya.
Elizabeth OdhiamboKenya National Blood Transfusion Services, Ministry of Health, Nairobi, Kenya.
Thomas RotichKenya National Blood Transfusion Services, Ministry of Health, Nairobi, Kenya.ORCID https://orcid.org/0000-0002-4699-2135
Irene OrgutKenya National Blood Transfusion Services, Ministry of Health, Nairobi, Kenya.
Sammy KiharaKenya National Blood Transfusion Services, Ministry of Health, Nairobi, Kenya.
Mark OtiendeKEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.ORCID https://orcid.org/0000-0002-1389-1813
Christian BottomleyDepartment of Infectious Diseases Epidemiology, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK.
Zonia N MupeKEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.ORCID https://orcid.org/0000-0002-2604-5309
Eunice W KaguciaKEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.ORCID https://orcid.org/0000-0002-4481-8889
Katherine E GallagherKEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.ORCID https://orcid.org/0000-0002-5604-7647
Anthony EtyangKEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.ORCID https://orcid.org/0000-0003-1267-6422
Shirine VollerKEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
John N GitongaKEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
Daisy MugoKEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.ORCID https://orcid.org/0000-0003-3128-2461
Charles N AgotiKEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
Edward OtienoKEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.ORCID https://orcid.org/0000-0002-8014-7306
Leonard NdwigaKEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.ORCID https://orcid.org/0000-0002-2936-1059
Teresa LambeNuffield Department of Medicine, Oxford University, Oxford, UK.ORCID https://orcid.org/0000-0001-7711-897X
Daniel WrightNuffield Department of Medicine, Oxford University, Oxford, UK.ORCID https://orcid.org/0000-0002-8114-1838
Edwine BarasaKEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
Benjamin TsofaKEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.ORCID https://orcid.org/0000-0003-1000-1771
Philip BejonKEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
Lynette I Ochola-OyierKEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
Ambrose Agweyu *KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.ORCID https://orcid.org/0000-0001-8760-1279
J Anthony G Scott *KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
George M Warimwe *KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.ORCID https://orcid.org/0000-0002-4911-6333
Kenya Medical Research Institute · KEKenya National Blood Transfusion Services · KEMinistry of Health · KEUniversity of Oxford · GBKenya School of Government · KELondon School of Hygiene & Tropical Medicine · GB

Funding

EPA EP-C-15-003Medical Research Council MR/R006083/1Medical Research Council MR/R010161/1Medical Research Council MR/S005293/1NIAID NIH HHS HHSN272201400008CWellcome Trust
6 · The paper itself

Abstract

The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Africa is poorly described. The first case of SARS-CoV-2 in Kenya was reported on 12 March 2020, and an overwhelming number of cases and deaths were expected, but by 31 July 2020, there were only 20,636 cases and 341 deaths. However, the extent of SARS-CoV-2 exposure in the community remains unknown. We determined the prevalence of anti-SARS-CoV-2 immunoglobulin G among blood donors in Kenya in April-June 2020. Crude seroprevalence was 5.6% (174 of 3098). Population-weighted, test-performance-adjusted national seroprevalence was 4.3% (95% confidence interval, 2.9 to 5.8%) and was highest in urban counties Mombasa (8.0%), Nairobi (7.3%), and Kisumu (5.5%). SARS-CoV-2 exposure is more extensive than indicated by case-based surveillance, and these results will help guide the pandemic response in Kenya and across Africa.

Indexed as

Blood DonorsAdolescentAdultAgedAntibodies, ViralCommunicable Disease ControlCOVID-19HumansImmunoglobulin GKenyaMiddle AgedSARS-CoV-2Seroepidemiologic StudiesYoung AdultAntibodies, ViralImmunoglobulin G

Identifiers

PMID33177105
PMCPMC7877494
OpenAlexW3104471981

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.