Evidence map›Paper›PMID 33177047›Full record

ArticleBMJ (Clinical research ed.)2020

Pregravid contraceptive use and fecundability: prospective cohort study.

Jennifer J Yland, Kathryn A Bresnick, Elizabeth E Hatch, Amelia K Wesselink, Ellen M Mikkelsen, Kenneth J Rothman, Henrik T Sørensen, Krista F Huybrechts, Lauren A Wise

Open access · hybridAbstract read
In one paragraph

Article in BMJ (Clinical research ed.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 38 citations in OpenAlex.

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  4. The association between levonorgestrel intrauterine devices and female fertility compared to other contraceptive methods: A historical cohort study.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Jennifer J YlandDepartment of Epidemiology, Boston University School of Public Health, 715 Albany Street, Boston, MA 02118 USA yland@bu.edu.ORCID 0000-0001-7870-8971
Kathryn A BresnickDepartment of Epidemiology, Boston University School of Public Health, 715 Albany Street, Boston, MA 02118 USA.
Elizabeth E HatchDepartment of Epidemiology, Boston University School of Public Health, 715 Albany Street, Boston, MA 02118 USA.
Amelia K WesselinkDepartment of Epidemiology, Boston University School of Public Health, 715 Albany Street, Boston, MA 02118 USA.
Ellen M MikkelsenDepartment of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
Kenneth J RothmanDepartment of Epidemiology, Boston University School of Public Health, 715 Albany Street, Boston, MA 02118 USA.
Henrik T SørensenDepartment of Epidemiology, Boston University School of Public Health, 715 Albany Street, Boston, MA 02118 USA.
Krista F HuybrechtsDivision of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Lauren A WiseDepartment of Epidemiology, Boston University School of Public Health, 715 Albany Street, Boston, MA 02118 USA.
Boston University · USAarhus University Hospital · DKBrigham and Women's Hospital · US

Funding

An internet-based preconception cohort study in North America and DenmarkR01HD086742 · NICHD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI LAUREN A WISE · 2016 to 2026
$6.7M
An internet based prospective study of time to pregnancyR01HD060680 · NICHD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI HATCH, ELIZABETH E · 2010 to 2014
$2.6M
BURPPE:BU Reproductive, Perinatal, and Pediatric Epidemiology Training ProgramT32HD052458 · NICHD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI WERLER, MARTHA M. · 2007 to 2016
$2.0M
A Pilot Study Of Internet Recruitment and follow-up among Reproductive Age WomenR21HD050264 · NICHD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI HATCH, ELIZABETH E · 2006 to 2007
$399k
Feasibility of an internet-based study of time-to-pregnancy in the United StatesR21HD072326 · NICHD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI WISE, LAUREN A · 2013 to 2014
$337k
NICHD NIH HHS R01 HD060680NICHD NIH HHS R01 HD086742NICHD NIH HHS R21 HD050264NICHD NIH HHS R21 HD072326NICHD NIH HHS T32 HD052458
6 · The paper itself

Abstract

objectiveTo evaluate the association between pregravid use of a variety of contraceptive methods and subsequent fecundability.

designProspective cohort study.

settingDenmark and North America, 2007-19.

participants17 954 women who had tried to conceive for up to six menstrual cycles at study entry. At baseline, participants reported their contraceptive histories, and personal, medical, and lifestyle characteristics.

main outcome measuresPregnancy, determined by bimonthly follow-up questionnaires for up to 12 months.

resultsApproximately 38% (n=6735) of participants had recently used oral contraceptives, 13% (n=2398) had used long acting reversible contraceptive methods, and 31% (n=5497) had used barrier methods. Women who had recently stopped using oral contraceptives, the contraceptive ring, and some long acting reversible contraceptive methods experienced short term delays in return of fertility compared with users of barrier methods. Use of injectable contraceptives was associated with decreased fecundability compared with use of barrier methods (fecundability ratio 0.65; 95% confidence interval 0.47 to 0.89). Users of injectable contraceptives had the longest delay in return of normal fertility (five to eight menstrual cycles), followed by users of patch contraceptives (four cycles), users of oral and ring contraceptives (three cycles), and users of hormonal and copper intrauterine devices and implant contraceptives (two cycles). Lifetime length of use of hormonal contraceptive methods was not associated with fecundability.

conclusionsUse of some hormonal contraceptive methods was associated with delays in return of fertility, with injectable contraceptives showing the longest delay. The findings indicated little or no lasting effect of long term use of these methods on fecundability.

Indexed as

Contraceptive Agents, FemaleFertilityAdultCohort StudiesContraception BehaviorDenmarkFemaleHumansPregnancyProspective StudiesSurveys and QuestionnairesUnited StatesContraceptive Agents, Female

Identifiers

PMID33177047
PMCPMC7656314
OpenAlexW3099326034

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.